(Q14905444)

https://platform.opentargets.org/evidence/ENSG00000213398/Orphanet_79292

based on heuristic

inferred from an Open Targets association score over 0.7

Norum disease

1 reference

stated in

Open Targets Platform

retrieved

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000213398/Orphanet_79293

based on heuristic

inferred from an Open Targets association score over 0.7

chromosome

human chromosome 16

genomic assembly

1 reference

1 reference

67939750

1 reference

67973653

1 reference

67944131

1 reference

67978034

phosphatidylcholine-sterol O-acyltransferase activity

1 reference

16q22.1

1 reference

15 May 2022

7 references

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

The high-resolution crystal structure of human LCAT

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

1 reference

18 July 2017

Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

O-acyltransferase activity

IPI

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

acyltransferase activity

1 reference

18 July 2017

apolipoprotein A-I binding

1 reference

18 July 2017

Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

2 references

4 references

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Cloning and expression of human lecithin-cholesterol acyltransferase cDNA

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

high-density lipoprotein particle

1 reference

18 July 2017

Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

2 references

phospholipid metabolic process

1 reference

18 July 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

phosphatidylcholine biosynthetic process

1 reference

18 July 2017

Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

steroid metabolic process

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

cholesterol metabolic process

5 references

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

The high-resolution crystal structure of human LCAT

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

cholesterol transport

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

very-low-density lipoprotein particle remodeling

1 reference

18 July 2017

Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

high-density lipoprotein particle remodeling

5 references

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

ApoA-I structure on discs and spheres. Variable helix registry and conformational states

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Remodeling of HDL remnants generated by scavenger receptor class B type I

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

cholesterol esterification

3 references

18 July 2017

The high-resolution crystal structure of human LCAT

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

Cloning and expression of human lecithin-cholesterol acyltransferase cDNA

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

18 July 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

lipoprotein biosynthetic process

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

A protein cofactor of lecithin:cholesterol acyltransferase

cholesterol homeostasis

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

reverse cholesterol transport

1 reference

18 July 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

phosphatidylcholine metabolic process

1 reference

18 July 2017

The high-resolution crystal structure of human LCAT

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

regulation of high-density lipoprotein particle assembly

1 reference

18 July 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04180

HomoloGene ID

68042

1 reference

15 May 2022

1 reference

68042

1 reference

68042

1 reference

68042

1

1 reference

28 April 2022

tibial nerve

2

1 reference

28 April 2022

left lobe of thyroid gland

3

1 reference

28 April 2022

right lobe of thyroid gland

4

1 reference

28 April 2022

ascending aorta

5

1 reference

28 April 2022

right coronary artery

6

1 reference

28 April 2022

canal of the cervix

7

1 reference

28 April 2022

left coronary artery

8

1 reference

28 April 2022

right lung

9

1 reference

28 April 2022

upper lobe of left lung

10

1 reference

28 April 2022

http://identifiers.org/ncbigene/3931

exact match

1 reference

stated in

Identifiers.org