(Q14911693)

DNA mismatch repair protein MutS, N-terminal domain, protein family

1 reference

DNA mismatch repair protein MutS, core domain superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

MutS, connector domain superfamily

1 reference

DNA mismatch repair protein MutS, connector domain, protein family

1 reference

DNA mismatch repair protein MutS, C-terminal domain, protein family

1 reference

DNA mismatch repair protein MutS, clamp, protein family

1 reference

DNA mismatch repair protein MutS, core domain, protein family

1 reference

DNA mismatch repair protein MutS-like, N-terminal domain, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

centromeric DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

mismatched DNA binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

14 February 2019

MSH2 deficient mice are viable and susceptible to lymphoid tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

14 February 2019

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

guanine/thymine mispair binding

3 references

24 April 2018

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

four-way junction DNA binding

IDA

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

heteroduplex DNA loop binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

double-strand/single-strand DNA junction binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

ATP-dependent activity, acting on DNA

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

single base insertion or deletion binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

magnesium ion binding

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

3 references

14 February 2019

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

14 February 2019

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

single-stranded DNA binding

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

protein kinase binding

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

guanine/thymine mispair binding

4 references

9 May 2019

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

single guanine insertion binding

single thymine insertion binding

dinucleotide repeat insertion binding

oxidized purine DNA binding

MutLalpha complex binding

protein homodimerization activity

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

mismatched DNA binding

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

MSH2 deficient mice are viable and susceptible to lymphoid tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

cell component

mismatch repair complex

1 reference

24 April 2018

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Mouse models for hereditary nonpolyposis colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Mouse models for hereditary nonpolyposis colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

biological process

B cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

mitotic intra-S DNA damage checkpoint signaling

1 reference

9 May 2019

Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

determination of adult lifespan

1 reference

9 May 2019

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

1 reference

9 May 2019

The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

somatic recombination of immunoglobulin genes involved in immune response

1 reference

14 February 2019

Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

double-strand break repair

1 reference

9 May 2019

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

24 April 2018

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

negative regulation of neuron apoptotic process

1 reference

9 May 2019

Mitochondrial dysfunction and increased sensitivity to excitotoxicity in mice deficient in DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss

germ cell development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

oxidative phosphorylation

1 reference

9 May 2019

Mitochondrial dysfunction and increased sensitivity to excitotoxicity in mice deficient in DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

1 reference

9 May 2019

DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss

male gonad development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

somatic hypermutation of immunoglobulin genes

6 references

9 May 2019

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

postreplication repair

4 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

cellular response to DNA damage stimulus

5 references

9 May 2019

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

somatic recombination of immunoglobulin gene segments

5 references

9 May 2019

The Sμ Tandem Repeat Region Is Critical for Ig Isotype Switching in the Absence of Msh2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

negative regulation of DNA recombination

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

21 references

24 April 2018

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Female embryonic lethality in mice nullizygous for both Msh2 and p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

24 April 2018

In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

meiotic gene conversion

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

maintenance of DNA repeat elements

negative regulation of reciprocal meiotic recombination

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

positive regulation of isotype switching to IgA isotypes

1 reference

9 May 2019

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

positive regulation of isotype switching to IgG isotypes

1 reference

9 May 2019

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

meiotic mismatch repair

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

pyrimidine dimer repair

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

22 references

9 May 2019

Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Female embryonic lethality in mice nullizygous for both Msh2 and p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

postreplication repair

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

double-strand break repair

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

mitotic recombination

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

interstrand cross-link repair

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

replication fork arrest

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

positive regulation of helicase activity

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

protein localization to chromatin

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247

negative regulation of DNA recombination

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247

DNA mismatch repair protein MutS, C-terminal

has part(s)

1 reference

DNA mismatch repair protein MutS, clamp

1 reference

DNA mismatch repair protein MutS, connector domain

1 reference

DNA mismatch repair protein MutS-like, N-terminal

1 reference

DNA mismatch repair protein MutS, core

1 reference