(Q28506440)

24 January 2017

title

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (English)

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24 January 2017

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GOA release 2020-03-11

author name string

C. Rada

1

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24 January 2017

M. R. Ehrenstein

2

1 reference

24 January 2017

M. S. Neuberger

3

1 reference

24 January 2017

C. Milstein

4

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24 January 2017

language of work or name

English

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publication date

1 July 1998

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24 January 2017

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24 January 2017

volume

9

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24 January 2017

issue

1

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24 January 2017

page(s)

135–141

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Mutation drift and repertoire shift in the maturation of the immune response

24 January 2017

cites work

1 reference

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7 January 2021

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

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7 January 2021

A new DNA sequence assembly program

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7 January 2021

Mismatch repair co-opted by hypermutation.

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7 January 2021

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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7 January 2021

Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements

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7 January 2021

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

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7 January 2021

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7 January 2021

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

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7 January 2021

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

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7 January 2021

Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptors

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7 January 2021

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

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7 January 2021

Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice

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7 January 2021

Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

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7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

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7 January 2021

Hyperresponsive B cells in CD22-deficient mice

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7 January 2021

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

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7 January 2021

Clonal selection and learning in the antibody system

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7 January 2021

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

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7 January 2021

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

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7 January 2021

The molecular basis of somatic hypermutation of immunoglobulin genes

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7 January 2021

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

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7 January 2021