Wikidata

(Q21101946)

English

Cullin 1

mammalian protein found in Homo sapiens

  • CUL1
  • cullin-1
  • CUL-1
In more languages

Statements

molecular function
protein binding
determination method
IPI
53 references
retrieved
1 January 2018
stated in
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Characterization of FBX25, encoding a novel brain-expressed F-box protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Impaired DNA damage checkpoint response in MIF-deficient mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Ribosomal proteins are targets for the NEDD8 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Mediator acts upstream of the transcriptional activator Gal4.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
TIP120A associates with cullins and modulates ubiquitin ligase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of nucleolar signalling to p53 through NEDDylation of L11
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
retrieved
1 January 2018
stated in
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IPI
cell component
SCF ubiquitin ligase complex
determination method
IDA
ISS
IEA
11 references
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
ISS
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IEA
retrieved
5 June 2018
stated in
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
The novel human DNA helicase hFBH1 is an F-box protein
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
5 June 2018
stated in
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13616&geneProductId=UniProtKB:Q13616
determination method
IDA
SCF ubiquitin ligase complex
determination method
IBA
IDA
IEA
ISS
12 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
ISS
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IEA
retrieved
1 January 2018
stated in
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
The novel human DNA helicase hFBH1 is an F-box protein
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
GOA
curator
UniProt
UniProt protein ID
Q13616
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616
determination method
IBA
biological process

Identifiers

 
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