Wikidata

(Q21114061)

English

Large tumor suppressor kinase 1

mammalian protein found in Homo sapiens

  • LATS (large tumor suppressor, Drosophila) homolog 1
  • LATS1
  • large tumor suppressor homolog 1
  • h-warts
  • serine/threonine-protein kinase LATS1
  • LATS, large tumor suppressor, homolog 1
  • WARTS protein kinase
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
23 references
retrieved
8 April 2019
stated in
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway
GOA
curator
UniProt
UniProt protein ID
O95835
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
GOA
curator
UniProt
UniProt protein ID
O95835
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2
GOA
curator
UniProt
UniProt protein ID
O95835
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway
GOA
curator
UniProt
UniProt protein ID
O95835
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular characterization of human homologs of yeast MOB1
GOA
curator
UniProt
UniProt protein ID
O95835
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Hippo pathway regulates Wnt/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
AMPK modulates Hippo pathway activity to regulate energy homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular characterization of human homologs of yeast MOB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Hippo pathway regulates Wnt/beta-catenin signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O95835
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IEA
retrieved
8 April 2019
stated in
A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis
GOA
curator
UniProt
UniProt protein ID
O95835
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IDA
retrieved
8 April 2019
stated in
The Hippo pathway regulates Wnt/beta-catenin signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835
determination method or standard
IBA
cell component
biological process

Identifiers

 
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