Wikidata

(Q21114975)

English

Ribosomal protein S6 kinase B1

mammalian protein found in Homo sapiens

  • serine/threonine kinase 14 alpha
  • p70-S6K 1
  • p70 S6 kinase, alpha
  • p70 S6K-alpha
  • p70 ribosomal S6 kinase alpha
  • ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • ribosomal protein S6 kinase beta-1
  • 70 kDa ribosomal protein S6 kinase 1
  • RPS6KB1
  • p70 S6 kinase alpha
  • p70 S6KA
  • ribosomal protein S6 kinase I
  • P70S6K1
  • serine/threonine-protein kinase 14A
In more languages

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
GOA
curator
UniProt
UniProt protein ID
P23443
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
UniProt
UniProt protein ID
P23443
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling
GOA
curator
UniProt
UniProt protein ID
P23443
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
Visualization of biochemical networks in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
retrieved
8 April 2019
stated in
The crosstalk of mTOR/S6K1 and Hedgehog pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443
determination method
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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