Wikidata

(Q21118153)

English

Farnesyltransferase, CAAX box, alpha

mammalian protein found in Homo sapiens

  • protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
  • type I protein geranyl-geranyltransferase alpha subunit
  • GGTase-I-alpha
  • Type I protein geranyl-geranyltransferase subunit alpha
  • FTase-alpha
  • ras proteins prenyltransferase subunit alpha
  • protein prenyltransferase alpha subunit repeat containing 2
  • FNTA
  • farnesyl-protein transferase alpha-subunit
  • CAAX farnesyltransferase subunit alpha
In more languages

Statements

molecular function
protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IPI
retrieved
8 April 2019
stated in
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IPI
retrieved
8 April 2019
stated in
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IPI
retrieved
8 April 2019
stated in
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IPI
protein farnesyltransferase activity
determination method
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49354
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IEA
retrieved
8 April 2019
stated in
Conversion of protein farnesyltransferase to a geranylgeranyltransferase
GOA
curator
UniProt
UniProt protein ID
P49354
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IDA
retrieved
8 April 2019
stated in
The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354
determination method
IBA
cell component
biological process

Identifiers

PDB structure ID
 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21118153&oldid=2022972557"