(Q21123297)

K Homology domain, type 1 superfamily

1 reference

Ribosomal protein S5 domain 2-type fold

1 reference

polyribonucleotide nucleotidyltransferase

1 reference

PNPase/RNase PH domain superfamily

1 reference

Exoribonuclease, PH domain 2 superfamily

1 reference

Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily

1 reference

Exoribonuclease, phosphorolytic domain 2, protein family

1 reference

RNA-binding domain, S1, protein family

1 reference

Exoribonuclease, phosphorolytic domain 1, protein family

1 reference

Polyribonucleotide nucleotidyltransferase, RNA-binding domain, protein family

1 reference

S1 domain, protein family

1 reference

K Homology domain, protein family

1 reference

K Homology domain, type 1, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

nucleotidyltransferase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

polyribonucleotide nucleotidyltransferase activity

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

3'-5'-exoribonuclease activity

3 references

polyribonucleotide nucleotidyltransferase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

mitochondrial intermembrane space

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

mitochondrial degradosome

1 reference

8 April 2019

Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

6 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

endoplasmic reticulum membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

negative regulation of growth

1 reference

8 April 2019

Down-regulation of Myc as a Potential Target for Growth Arrest Induced by Human Polynucleotide Phosphorylase (hPNPase) in Human Melanoma Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

mRNA catabolic process

3 references

8 April 2019

8 April 2019

Down-regulation of Myc as a Potential Target for Growth Arrest Induced by Human Polynucleotide Phosphorylase (hPNPase) in Human Melanoma Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

nuclear polyadenylation-dependent mRNA catabolic process

1 reference

8 April 2019

The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

mitochondrial RNA catabolic process

1 reference

26 September 2017

Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

cellular response to interferon-beta

1 reference

8 April 2019

Defining the mechanism by which IFN-beta dowregulates c-myc expression in human melanoma cells: pivotal role for human polynucleotide phosphorylase (hPNPaseold-35)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

nucleic acid phosphodiester bond hydrolysis

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

mitochondrial RNA 3'-end processing

1 reference

26 September 2017

Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts

RNA catabolic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

mitochondrial mRNA polyadenylation

1 reference

8 April 2019

Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

protein homotrimerization

IMP

mitochondrial RNA 5'-end processing

1 reference

8 April 2019

Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

regulation of cellular senescence

IMP

1 reference

8 April 2019

Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

cellular response to oxidative stress

1 reference

8 April 2019

Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

rRNA import into mitochondrion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

positive regulation of miRNA catabolic process

1 reference

8 April 2019

Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

protein homooligomerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

positive regulation of mitochondrial RNA catabolic process

1 reference

8 April 2019

Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

RNA import into mitochondrion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

RNA phosphodiester bond hydrolysis, exonucleolytic

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

response to growth hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCS8&geneProductId=UniProtKB:Q8TCS8

mitochondrial mRNA catabolic process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

mitochondrial RNA processing

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCS8

IBA

RNA catabolic process

RNA-binding domain, S1

1 reference

K Homology domain, type 1

1 reference

S1 domain

1 reference

K Homology domain

1 reference

Exoribonuclease, phosphorolytic domain 1

1 reference

Exoribonuclease, phosphorolytic domain 2

1 reference

Polyribonucleotide nucleotidyltransferase, RNA-binding domain

1 reference