(Q21125178)

English

Sestrin 2

mammalian protein found in Homo sapiens

hypoxia induced gene 95
SESN2
Hypoxia-induced gene
sestrin-2
hypoxia-induced

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58004

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58004

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

11 references

8 April 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

SZT2 dictates GATOR control of mTORC1 signalling.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrin2 is a leucine sensor for the mTORC1 pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

oxidoreductase activity, acting on peroxide as acceptor

determination method

1 reference

24 April 2018

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

oxidoreductase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

GDP-dissociation inhibitor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

leucine binding

determination method

3 references

8 April 2019

Sestrin2 is a leucine sensor for the mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

determination method

5 references

24 April 2018

Sestrin2 is a leucine sensor for the mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

Atg1/ULK1 kinase complex

determination method

1 reference

8 April 2019

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

determination method

3 references

determination method

6 references

8 April 2019

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrin2 is a leucine sensor for the mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

biological process

mitochondrial DNA metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

mitochondrion organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

protein kinase B signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

regulation of cAMP-dependent protein kinase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

response to insulin

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

response to glucose

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

glucose homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

regulation of response to reactive oxygen species

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

triglyceride homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

fatty acid beta-oxidation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

negative regulation of TORC1 signaling

determination method

8 references

24 April 2018

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Hepatoprotective role of Sestrin2 against chronic ER stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Sestrin2 is a leucine sensor for the mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

determination method

1 reference

8 April 2019

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

positive regulation of macroautophagy

determination method

1 reference

24 April 2018

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

cellular response to leucine

determination method

1 reference

24 April 2018

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

positive regulation of protein localization to nucleus

determination method

1 reference

8 April 2019

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

cellular oxidant detoxification

determination method

3 references

8 April 2019

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

positive regulation of lipophagy

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

cellular response to amino acid starvation

determination method

1 reference

8 April 2019

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

cellular response to glucose starvation

determination method

1 reference

8 April 2019

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

cellular response to leucine starvation

determination method

1 reference

24 April 2018

Sestrin2 is a leucine sensor for the mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004

determination method

regulation of gluconeogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

cellular response to amino acid stimulus

determination method

3 references

8 April 2019

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

negative regulation of TORC1 signaling

determination method

9 references

8 April 2019

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Hepatoprotective role of Sestrin2 against chronic ER stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrin2 is a leucine sensor for the mTORC1 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000253063

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000253063

ENSP00000496365

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496365

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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