(Q28116006)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

Sestrin2 is a leucine sensor for the mTORC1 pathway (English)

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

GOA release 2020-03-11

Sestrin 2

1 reference

GOA release 2020-03-11

Sestrin 1

1 reference

GOA release 2020-03-11

author

David M. Sabatini

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

author name string

Lynne Chantranupong

2

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Kuang Shen

4

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Rachel L Wolfson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Robert A Saxton

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Sonia M Scaria

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Jason R Cantor

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

language of work or name

English

0 references

publication date

8 October 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

volume

351

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

page(s)

43-48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

issue

6268

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

26 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

The TOR pathway comes of age

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Amino acids and mTORC1: from lysosomes to disease

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Nutrient-sensing mechanisms across evolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Localization of Rheb to the endomembrane is critical for its signaling function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Branched-chain amino acid metabolism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

20 March 2017

1 reference

Crossref

https://api.crossref.org/works/10.1126/SCIENCE.AAB2674

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Ruminations on dietary restriction and aging.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Potential importance of leucine in treatment of obesity and the metabolic syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

The levels of individual free amino acids in the plasma of normal man at various intervals after a high-protein meal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Nutrients and growth factors in mTORC1 activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4698017

Protein, amino acids and the control of food intake

27 November 2018

1 reference

12 December 2020

Label-free characterization of carbonic anhydrase-novel inhibitor interactions using surface plasmon resonance, isothermal titration calorimetry and fluorescence-based thermal shift assays

1 reference

12 December 2020

Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes

1 reference

12 December 2020

Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets

1 reference

12 December 2020

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

12 December 2020

Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.AAB2674

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

ADS bibcode

2016Sci...351...43W

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26449471%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

2 references