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Amino acids and mTORC1: from lysosomes to disease
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Europe PubMed Central
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3432651
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6 February 2020
title
Amino acids and mTORC1: from lysosomes to disease
(English)
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Europe PubMed Central
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3432651
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6 February 2020
author
Alejo Efeyan
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1
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Europe PubMed Central
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3432651
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22749019%20AND%20SRC:MED&resulttype=core&format=json
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6 February 2020
David M. Sabatini
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3
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Europe PubMed Central
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3432651
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6 February 2020
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Roberto Zoncu
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2
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6 February 2020
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English
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publication date
28 June 2012
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6 February 2020
published in
Trends in Molecular Medicine
2 references
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PubMed
stated in
Europe PubMed Central
PMCID
3432651
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6 February 2020
volume
18
2 references
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PubMed
stated in
Europe PubMed Central
PMCID
3432651
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22749019%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
page(s)
524-533
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Europe PubMed Central
PMCID
3432651
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6 February 2020
issue
9
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PubMed
stated in
Europe PubMed Central
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3432651
reference URL
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6 February 2020
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7 April 2017
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7 April 2017
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
An activating mutation of AKT2 and human hypoglycemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Regulation of TFEB and V-ATPases by mTORC1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Spatial coupling of mTOR and autophagy augments secretory phenotypes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Protein misfolding disorders and macroautophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
The late endosome is essential for mTORC1 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
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28 September 2017
An emerging role of mTOR in lipid biosynthesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
The yeast lysosome-like vacuole: endpoint and crossroads
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Dissecting eIF4E action in tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
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28 September 2017
Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Dynamic aspects of vacuolar and cytosolic amino acid pools of Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 September 2017
Lysosomal positioning coordinates cellular nutrient responses.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
31 May 2018
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
31 May 2018
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
31 May 2018
Amino acid availability regulates p70 S6 kinase and multiple translation factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
31 May 2018
Germline mutations in PTEN are present in Bannayan-Zonana syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
31 May 2018
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
31 May 2018
Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 November 2018
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 November 2018
The structure of CodY, a GTP- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 November 2018
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 November 2018
Attractant signaling by an aspartate chemoreceptor dimer with a single cytoplasmic domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432651
retrieved
28 November 2018
Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22749019
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Response of Adult Rats to Low Dietary Levels of Essential Amino Acids
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22749019
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Lysosomal pool of free-amino acids
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22749019
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.MOLMED.2012.05.007
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1681408
stated in
Europe PubMed Central
PMCID
3432651
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22749019%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
OpenCitations bibliographic resource ID
1681408
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1681408
PMCID
3432651
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1681408
stated in
Europe PubMed Central
PMCID
3432651
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22749019%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
PubMed ID
22749019
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1681408
stated in
Europe PubMed Central
PMCID
3432651
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22749019%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
ResearchGate publication ID
228100709
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