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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
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scholarly article
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
title
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
(English)
1 reference
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
main subject
Sestrin 3
1 reference
stated in
GOA release 2020-03-11
Sestrin 2
1 reference
stated in
GOA release 2020-03-11
Sestrin 1
1 reference
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GOA release 2020-03-11
author
Steven P. Gygi
series ordinal
9
object named as
Steven P. Gygi
1 reference
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
Eric Spooner
series ordinal
7
object named as
Eric Spooner
1 reference
stated in
PubMed
PubMed ID
25263562
retrieved
4 January 2017
David M. Sabatini
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10
object named as
David M. Sabatini
1 reference
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
author name string
Lynne Chantranupong
series ordinal
1
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
Rachel L. Wolfson
series ordinal
2
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PubMed
PubMed ID
25263562
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4 January 2017
Jose M. Orozco
series ordinal
3
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
Robert A. Saxton
series ordinal
4
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
Sonia M. Scaria
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5
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
Liron Bar-Peled
series ordinal
6
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
Marta Isasa
series ordinal
8
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
publication date
9 October 2014
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stated in
PubMed
PubMed ID
25263562
retrieved
4 January 2017
published in
Cell Reports
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
volume
9
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
page(s)
1–8
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
issue
1
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PubMed
PubMed ID
25263562
retrieved
4 January 2017
cites work
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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20 March 2017
mTOR signaling in growth control and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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20 March 2017
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Amino acids and mTORC1: from lysosomes to disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Nutrient sensing, metabolism, and cell growth control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Regulation of mTORC1 by amino acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Nutrient regulation of the mTOR complex 1 signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Localization of Rheb to the endomembrane is critical for its signaling function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
Rheb binds and regulates the mTOR kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
20 March 2017
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
7 April 2017
Regulation of TORC1 by Rag GTPases in nutrient response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
7 April 2017
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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7 April 2017
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
7 April 2017
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
retrieved
29 September 2017
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
A growing role for mTOR in promoting anabolic metabolism
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
Stressin' Sestrins take an aging fight
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
Regulation of the small GTPase Rheb by amino acids.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
Rheb promotes cell growth as a component of the insulin/TOR signalling network
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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29 September 2017
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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27 November 2018
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4223866
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27 November 2018
Identifiers
DOI
10.1016/J.CELREP.2014.09.014
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1647221
OpenCitations bibliographic resource ID
1647221
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1647221
PMCID
4223866
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1647221
PubMed ID
25263562
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1647221
ResearchGate publication ID
266263242
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