(Q37208207)

18 August 2017

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases (English)

1 reference

Folliculin interacting protein 1

18 August 2017

1 reference

GOA release 2020-03-11

1 reference

positive regulation of TOR signaling

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Constance S Petit

series ordinal

1

1 reference

18 August 2017

Agnes Roczniak-Ferguson

series ordinal

2

1 reference

18 August 2017

Shawn M Ferguson

series ordinal

3

1 reference

18 August 2017

language of work or name

English

0 references

publication date

1 September 2013

1 reference

18 August 2017

Journal of Cell Biology

1 reference

18 August 2017

202

1 reference

18 August 2017

7

1 reference

18 August 2017

1107-1122

1 reference

describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3787382/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

6 September 2017

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The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs

6 September 2017

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Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

6 September 2017

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Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin

6 September 2017

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Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics

6 September 2017

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

6 September 2017

1 reference

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Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

6 September 2017

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The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

6 September 2017

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

6 September 2017

1 reference

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SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling

6 September 2017

1 reference

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Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

6 September 2017

1 reference

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mTOR signaling in growth control and disease

6 September 2017

1 reference

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Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

6 September 2017

1 reference

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Leucyl-tRNA synthetase controls TORC1 via the EGO complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

6 September 2017

1 reference

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AMPK and mTOR in cellular energy homeostasis and drug targets

6 September 2017

1 reference

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mTOR signaling in disease

6 September 2017

1 reference

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

6 September 2017

1 reference

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Regulation of TFEB and V-ATPases by mTORC1.

6 September 2017

1 reference

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High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

6 September 2017

1 reference

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A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae

6 September 2017

1 reference

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Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

6 September 2017

1 reference

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Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

6 September 2017

1 reference

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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

6 September 2017

1 reference

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Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

A gene network regulating lysosomal biogenesis and function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Molecular mechanisms of mTOR-mediated translational control

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Regulation of TORC1 by Rag GTPases in nutrient response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

The chemical genomic portrait of yeast: uncovering a phenotype for all genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Unique mutation, accelerated mTOR signaling and angiogenesis in the pulmonary cysts of Birt-Hogg-Dubé syndrome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Glutaminolysis activates Rag-mTORC1 signaling.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787382

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24081491

12 December 2020

inferred from PubMed ID database lookup

Increased sensitivity of the indirect immunofluorescence method by use of a tertiary fluorochrome-labeled antibody

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24081491

12 December 2020

inferred from PubMed ID database lookup

Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24081491

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1083/JCB.201307084

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

24081491

1 reference