(Q33354615)

26 July 2017

Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin (English)

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26 July 2017

Andrew R Tee

1

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author name string

Arnim Pause

series ordinal

2

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26 July 2017

1 September 2013

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26 July 2017

6

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based on heuristic

inferred from page(s)

published in

Familial Cancer

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26 July 2017

12

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26 July 2017

3

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26 July 2017

367-372

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https://scigraph.springernature.com/pub.10.1007/s10689-012-9576-9

26 July 2017

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cites work

Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Therapeutic targeting the loss of the birt-hogg-dube suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Novel mutations in the BHD gene and absence of loss of heterozygosity in fibrofolliculomas of Birt-Hogg-Dubé patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Identification and characterization of a novel folliculin-interacting protein FNIP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.

21 January 2018

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog.

21 January 2018

1 reference

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Natural history of the Nihon rat model of BHD.

21 January 2018

1 reference

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Switching TGFβ from a tumor suppressor to a tumor promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10689-012-9576-9

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23096221

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Xp11.2 translocation renal cell carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23096221

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S10689-012-9576-9

1 reference

PubMed ID

23096221

Dimensions Publication ID

26 July 2017

0 references

1 reference

PubMed ID

23096221