(Q21131825)

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HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice

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HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice (English)

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object named as

Thaiz Ferraz Borin

1

author given names

Thaiz Ferraz

author last names

Borin

1 reference

16 August 2022

author name string

Debora A P C Zuccari

2

author given names

Debora A P C

author last names

Zuccari

1 reference

16 August 2022

Bruna V Jardim-Perassi

3

author given names

Bruna V

author last names

Jardim-Perassi

1 reference

16 August 2022

Lívia C Ferreira

4

author given names

Lívia C

author last names

Ferreira

1 reference

16 August 2022

A S M Iskander

5

author given names

A S M

author last names

Iskander

1 reference

16 August 2022

Nadimpalli Ravi S Varma

6

author given names

Nadimpalli Ravi S

author last names

Varma

1 reference

16 August 2022

Adarsh Shankar

7

author given names

Adarsh

author last names

Shankar

1 reference

16 August 2022

Austin M Guo

8

author given names

Austin M

author last names

Guo

1 reference

16 August 2022

Guillermo Scicli

9

author given names

Guillermo

author last names

Scicli

1 reference

16 August 2022

Ali S Arbab

10

author given names

Ali S

author last names

Arbab

1 reference

16 August 2022

language of work or name

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publication date

2014

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9

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12

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e116247

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copyright license

Creative Commons Attribution 4.0 International

30 December 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

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HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

19 March 2017

Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

The role of the VEGF-C/VEGFRs axis in tumor progression and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

20-HETE-producing enzymes are up-regulated in human cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

20-HETE in neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Antiangiogenic therapy for breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Angiogenesis and breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Human cord blood-derived AC133+ progenitor cells preserve endothelial progenitor characteristics after long term in vitro expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Tyrosine kinase blockers: new hope for successful cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Management of breast cancer--Part II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Management of breast cancer--part I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Inhibitors of cytochrome P450 4A suppress angiogenic responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

12 September 2017

Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

27 September 2017

Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

27 September 2017

In vivo tumor angiogenesis imaging with site-specific labeled (99m)Tc-HYNIC-VEGF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

27 September 2017

9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

27 September 2017

Blood vessel formation: what is its molecular basis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

27 September 2017

Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280215

30 May 2018

20-HETE can act as a nonhypoxic regulator of HIF-1alpha in human microvascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116247

21 January 2018

Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in human type 2 diabetic arterial vasculature.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116247

21 January 2018

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0116247

21 January 2018

Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25549350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by vascular endothelial growth factor receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25549350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinases generate angiostatin: effects on neovascularization

1 reference

https://pubmed.ncbi.nlm.nih.gov/25549350

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0116247

1 reference

https://api.fatcat.wiki/v0/release/gg4yzemiabccnf6p2cwlsee3ca

30 July 2022

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2014PLoSO...9k6247B

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release_gg4yzemiabccnf6p2cwlsee3ca

1 reference

https://api.fatcat.wiki/v0/release/gg4yzemiabccnf6p2cwlsee3ca

30 July 2022

based on heuristic

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1 reference

https://api.fatcat.wiki/v0/release/gg4yzemiabccnf6p2cwlsee3ca

30 July 2022

based on heuristic

mapped directly with Wikidata item

1 reference

https://api.fatcat.wiki/v0/release/gg4yzemiabccnf6p2cwlsee3ca

30 July 2022

based on heuristic

mapped directly with Wikidata item

ResearchGate publication ID

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