(Q21131978)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

title

St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

0 references

1 reference

1 reference

4

Dirk Lang

Dirk

Lang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

2

Benjamin Loos

Benjamin

Loos

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Britta Kleemann

1

Britta

Kleemann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Thomas J Scriba

series ordinal

3

author given names

Thomas J

author last names

Scriba

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Lester M Davids

series ordinal

5

author given names

Lester M

author last names

Davids

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

language of work or name

English

0 references

publication date

30 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

page(s)

e103762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

11 March 2020

copyright license

start time

30 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4116257/fullTextXML

inferred from PubMed Central ID database lookup

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Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy

19 March 2017

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Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms

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Nitrosylhemoglobin in photodynamically stressed human tumors growing in nude mice

12 September 2017

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ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

12 September 2017

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12 September 2017

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AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.

12 September 2017

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Comparison of Stain-Free gels with traditional immunoblot loading control methodology.

12 September 2017

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Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm.

12 September 2017

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Associations between environmental factors and incidence of cutaneous melanoma. Review

12 September 2017

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Cell death response of U87 glioma cells on hypericin photoactivation is mediated by dynamics of hypericin subcellular distribution and its aggregation in cellular organelles

12 September 2017

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Photodynamic therapy in melanoma--an update

12 September 2017

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Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death

12 September 2017

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Generation and clonal isolation of retinal stem cells from human embryonic stem cells

12 September 2017

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Killing a cancer: what are the alternatives?

12 September 2017

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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

12 September 2017

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A brief history of melanoma: from mummies to mutations

12 September 2017

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Molecular response to hypericin-induced photodamage.

12 September 2017

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Daylight photodynamic therapy for actinic keratosis: an international consensus: International Society for Photodynamic Therapy in Dermatology

12 September 2017

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Photodynamic therapy of cancer: an update

12 September 2017

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Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells

12 September 2017

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PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

12 September 2017

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Combating melanoma: the use of photodynamic therapy as a novel, adjuvant therapeutic tool

12 September 2017

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Apoptosis-inducing factor: structure, function, and redox regulation

12 September 2017

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Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.

12 September 2017

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Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications

12 September 2017

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Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage

12 September 2017

1 reference

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Photodynamic therapy and cell death pathways

12 September 2017

1 reference

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ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

12 September 2017

1 reference

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Hypericins as potential leads for new therapeutics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

The multifaceted photocytotoxic profile of hypericin

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Influence of melanosome dynamics on melanoma drug sensitivity.

12 September 2017

1 reference

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Autophagy in cutaneous malignant melanoma

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Apoptosis and necrosis: detection, discrimination and phagocytosis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Regulation of melanogenesis--controversies and new concepts

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Treatments for metastatic melanoma: synthesis of evidence from randomized trials

12 September 2017

1 reference

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AIF-mediated programmed necrosis: a highly regulated way to die.

12 September 2017

1 reference

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Melanophages reside in hypermelanotic, aberrantly glycosylated tumor areas and predict improved outcome in primary cutaneous malignant melanoma

12 September 2017

1 reference

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Molecular effectors of multiple cell death pathways initiated by photodynamic therapy

12 September 2017

1 reference

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Melanoma biology and new targeted therapy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Can St John's wort (hypericin) ingestion enhance the erythemal response during high-dose ultraviolet A1 therapy?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Molecular diagnostics in melanoma.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Antimetastatic activity of the photodynamic agent hypericin in the dark

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Quinone chemistry and melanogenesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Beta1,6-branched oligosaccharides and coarse vesicles: a common, pervasive phenotype in melanoma and other human cancers

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Interactions of human Myosin Va isoforms, endogenously expressed in human melanocytes, are tightly regulated by the tail domain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Hypericin: a new laser phototargeting agent for human cancer cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Comparative in vitro study on the characteristics of different photosensitizers employed in PDT.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Hypericin hydroquinone: potential as a red-far red photosensitizer?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Mitochondrial targeting of human protoporphyrinogen oxidase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Characterization of apoptosis induced by photodynamic treatment with hypericin in A431 human epidermoid carcinoma cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Induction of apoptosis by Hypericin through activation of caspase-3 in human carcinoma cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Different pathways mediate cytochrome c release after photodynamic therapy with hypericin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116257

The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors

27 September 2017

1 reference

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The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting

30 May 2018

1 reference

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Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.

30 May 2018

1 reference

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Fate of l-[3,5-3H]tyrosine in cell-free extracts and tissue cultures of melanoma cells: A new assay method for tyrosinase in living cells

30 May 2018

1 reference

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Mammalian tyrosinase. A comparison of tyrosine hydroxylation and melanin formation

30 May 2018

1 reference

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Anti-angiogenic activities of hypericin in vivo: potential for ophthalmologic applications

30 May 2018

1 reference

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Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry.

21 January 2018

1 reference

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Transplantable melanomas in gerbils (Meriones unguiculatus). II: melanogenesis.

21 January 2018

1 reference

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Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.

21 January 2018

1 reference

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The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells.

21 January 2018

1 reference

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Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin

21 January 2018

1 reference

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Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8.

21 January 2018

1 reference

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Nutrient sensing and insulin signaling in neuropeptide-expressing immortalized, hypothalamic neurons: A cellular model of insulin resistance

21 January 2018

1 reference

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The correlation between hydrophilicity of hypericins and helianthrone: internalization mechanisms, subcellular distribution and photodynamic action in colon carcinoma cells

21 January 2018

1 reference

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Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis

21 January 2018

1 reference

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The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

21 January 2018

1 reference

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Weather conditions and daylight-mediated photodynamic therapy: protoporphyrin IX-weighted daylight doses measured in six geographical locations

21 January 2018

1 reference

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Interactive transport, subcellular relocation and enhanced phototoxicity of hypericin encapsulated in guanidinylated liposomes via molecular recognition

29 November 2018

1 reference

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Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells

29 November 2018

1 reference

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Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide.

29 November 2018

1 reference

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From the Photosensitizer Hypericin to the Photoreceptor Stentorin- The Chemistry of Phenanthroperylene Quinones.

29 November 2018

1 reference

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What's the use of generating melanin?

29 November 2018

1 reference

12 December 2020

That which does not kill me makes me stronger: adapting to chronic ER stress

1 reference

12 December 2020

Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp: a randomized multicentre study

1 reference

12 December 2020

Separation of pigmented and albino melanocytes and the concomitant evaluation of endogenous peroxide content using flow cytometry

1 reference

12 December 2020

Molecular species of plasminogen activators secreted by normal and neoplastic human cells

1 reference

12 December 2020

Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: selective review and hypothesis

1 reference

12 December 2020

A randomized, multicentre study of directed daylight exposure times of 1½ vs. 2½ h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp

1 reference

12 December 2020

Why do melanomas get so dark?

1 reference

12 December 2020

1 reference

12 December 2020

Phototoxic effects of Hypericum extract in cultures of human keratinocytes compared with those of psoralen

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0103762

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

0 references

release_i77yteeguveb7jci4zvcsfnuje

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/i77yteeguveb7jci4zvcsfnuje

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PubMed publication ID

25076130

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25076130%20AND%20SRC:MED&resulttype=core&format=json