(Q21132123)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54252

Josephin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin interacting motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

Lys63-specific deubiquitinase activity

1 reference

8 April 2019

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

cysteine-type peptidase activity

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

Lys48-specific deubiquitinase activity

1 reference

8 April 2019

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

6 references

8 April 2019

Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Imbalances in p97 co-factor interactions in human proteinopathy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

identical protein binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

ubiquitin protein ligase binding

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 January 2018

A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 January 2018

Ataxin-3 is a multivalent ligand for the parkin Ubl domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

thiol-dependent deubiquitinase

IPI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

histone deacetylase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

thiol-dependent deubiquitinase

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

ubiquitin protein ligase binding

IBA

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Ataxin-3 is a multivalent ligand for the parkin Ubl domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

endoplasmic reticulum membrane

cell component

1 reference

8 April 2019

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

27 February 2018

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 reference

1 January 2018

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

mitochondrial membranes

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

nuclear inclusion body

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

nucleotide-excision repair

IBA

biological process

1 reference

8 April 2019

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

regulation of transcription, DNA-templated

TAS

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

protein K48-linked deubiquitination

1 reference

8 April 2019

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

positive regulation of ERAD pathway

IDA

1 reference

8 April 2019

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

transcription, DNA-templated

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

nervous system development

1 reference

8 April 2019

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

protein K63-linked deubiquitination

1 reference

8 April 2019

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

intermediate filament cytoskeleton organization

IDA

1 reference

8 April 2019

Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

protein localization to cytosolic proteasome complex involved in ERAD pathway

1 reference

8 April 2019

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

microtubule cytoskeleton organization

1 reference

8 April 2019

Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

actin cytoskeleton organization

1 reference

8 April 2019

Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

chemical synaptic transmission

1 reference

8 April 2019

Trinucleotide expansion within the MJD1 gene presents clinically as spinocerebellar ataxia and occurs most frequently in German SCA patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

TAS

protein deubiquitination

3 references

27 February 2018

27 February 2018

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252

ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

protein quality control for misfolded or incompletely synthesized proteins

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

regulation of cell-substrate adhesion

1 reference

1 January 2018

Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

cellular response to heat

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

monoubiquitinated protein deubiquitination

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

cellular response to misfolded protein

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

protein deubiquitination

4 references

8 April 2019

8 April 2019

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

histone H3 deacetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252

Ubiquitin interacting motif

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54252

Josephin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54252

Identifiers

MeSH descriptor ID

D000067699

subject named as

Ataxin-3

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference