(Q24337541)

cyclin dependent kinase 5

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Caspase 1

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negative regulation of neuron death

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André Karch

6

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Jörg B. Schulz

object named as

Jörg B Schulz

8

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author name string

Jan Liman

1

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Sebastian Deeg

2

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Aaron Voigt

3

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Hannes Voßfeldt

4

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Christoph P Dohm

5

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Jochen Weishaupt

7

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Mathias Bähr

9

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Pawel Kermer

Journal of Neurochemistry

10

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language of work or name

English

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publication date

June 2014

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published in

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volume

129

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issue

6

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page(s)

1013-23

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cites work

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

1 reference

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

21 January 2018

1 reference

Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.

21 January 2018

1 reference

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

21 January 2018

1 reference

Machado-Joseph-Azorean disease. A ten-year study.

21 January 2018

1 reference

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

21 January 2018

1 reference

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

21 January 2018

1 reference

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

A survey of spinocerebellar ataxia in South Brazil - 66 new cases with Machado-Joseph disease, SCA7, SCA8, or unidentified disease-causing mutations.

21 January 2018

1 reference

Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3.

21 January 2018

1 reference

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

21 January 2018

1 reference

Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis

21 January 2018

1 reference

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

Machado-Joseph disease mutations as the genetic basis of most spinocerebellar ataxias in Germany

21 January 2018

1 reference

Role of proteolysis in polyglutamine disorders

21 January 2018

1 reference

Toxic proteins in neurodegenerative disease

21 January 2018

1 reference

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

1 reference

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

21 January 2018

1 reference

Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction

21 January 2018

1 reference

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins

21 January 2018

1 reference

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

21 January 2018

1 reference