(Q44893930)

7 December 2017

title

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3. (English)

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7 December 2017

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Sarah J Shoesmith Berke

1

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7 December 2017

Francisca A Flores Schmied

2

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7 December 2017

Ewout R Brunt

3

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7 December 2017

Lisa M Ellerby

4

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7 December 2017

Henry L Paulson

5

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7 December 2017

language of work or name

English

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publication date

1 May 2004

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Journal of Neurochemistry

7 December 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

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7 December 2017

volume

89

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7 December 2017

issue

4

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7 December 2017

page(s)

908-918

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Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

7 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Treatment of COS-7 cells with proteasome inhibitors or gamma-interferon reduces the increase in caspase 3 activity associated with staurosporine-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Caspase activation pathways induced by staurosporine and low potassium: role of caspase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

High level expression of expanded full-length ataxin-3 in vitro causes cell death and formation of intranuclear inclusions in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Heterogeneous intracellular localization and expression of ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

21 January 2018

Caspases on the brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

Glutamine repeats and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02369.X

10.1111/J.1471-4159.2004.02369.X

21 January 2018

Identifiers

DOI

1 reference

7 December 2017

1 reference