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Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3.
scientific article published on 25 September 2009
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
title
Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
main subject
Drosophila
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author
Nancy M. Bonini
series ordinal
4
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
author name string
Joonil Jung
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Kexiang Xu
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2
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Derek Lessing
series ordinal
3
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
publication date
25 September 2009
1 reference
stated in
Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
published in
Human Molecular Genetics
1 reference
stated in
Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
volume
18
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
issue
24
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
page(s)
4843-4852
1 reference
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Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
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RNA toxicity is a component of ataxin-3 degeneration in Drosophila
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Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila
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A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice
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23 August 2017
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
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23 August 2017
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation
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23 August 2017
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity
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23 August 2017
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease
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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
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Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain
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23 August 2017
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.
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14 September 2017
Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila
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14 September 2017
Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
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A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
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14 September 2017
Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.
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26 June 2018
CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease
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2 September 2018
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
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PubMed Central
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2 September 2018
Small N-terminal mutant huntingtin fragments, but not wild type, are mainly present in monomeric form: Implications for pathogenesis
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2 September 2018
Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers
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2 September 2018
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
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2 September 2018
Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
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PubMed Central
reference URL
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2 September 2018
Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components
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stated in
PubMed Central
reference URL
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2 September 2018
Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells
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PubMed Central
reference URL
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retrieved
2 September 2018
Identifiers
DOI
10.1093/HMG/DDP456
1 reference
stated in
Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
PMC publication ID
2778376
1 reference
stated in
Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
PubMed publication ID
19783548
1 reference
stated in
Europe PubMed Central
PMC publication ID
2778376
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19783548%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
ResearchGate publication ID
26840375
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