(Q40135127)

17 September 2017

title

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3. (English)

1 reference

17 September 2017

2

F Ulrich Hartl

1 reference

17 September 2017

Annette Haacke

1

1 reference

17 September 2017

Peter Breuer

series ordinal

3

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17 September 2017

language of work or name

English

0 references

publication date

8 May 2007

1 reference

Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

26

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17 September 2017

page(s)

18851-18856

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Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

17 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Huntingtin is degraded to small fragments by calpain after ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

The HD mutation does not alter neuronal death in the striatum of Hdh(Q92) knock-in mice after mild focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

The calpain family and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Proteasome inhibitors: valuable new tools for cell biologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

On the sequential determinants of calpain cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611914200

21 January 2018

Identifiers

DOI

10.1074/JBC.M611914200

1 reference

release_uk5a4qxz6nfebo6dy5wmmbuanm

17 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uk5a4qxz6nfebo6dy5wmmbuanm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference