(Q21261309)

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Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+

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Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+ (English)

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David J. Waxman

3

object named as

David J Waxman

author given names

David J

author last names

Waxman

1 reference

Dimensions Publication ID

18 August 2022

author name string

Joshua C Doloff

1

author given names

Joshua C

author last names

Doloff

1 reference

Dimensions Publication ID

18 August 2022

Ting Su

2

author given names

Ting

author last names

Su

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Dimensions Publication ID

18 August 2022

language of work or name

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publication date

2010

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10

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1

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487

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Bystander or no bystander for gene directed enzyme prodrug therapy

1 reference

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12 September 2017

Recent progress in gene-directed enzyme prodrug therapy: an emerging cancer treatment

1 reference

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12 September 2017

Prodrug cancer gene therapy.

1 reference

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12 September 2017

Conditionally replicating adenoviruses for cancer treatment.

1 reference

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12 September 2017

Suicide genes for cancer therapy

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12 September 2017

Targeted and shielded adenovectors for cancer therapy

1 reference

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12 September 2017

Genetic identification of adenovirus type 5 genes that influence viral spread

1 reference

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12 September 2017

Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer

1 reference

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12 September 2017

From bench to bedside for gene-directed enzyme prodrug therapy of cancer

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12 September 2017

Replication-selective oncolytic viruses in the treatment of cancer.

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12 September 2017

Gene-directed enzyme prodrug therapy: a current assessment.

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12 September 2017

Harnessing apoptosis for improved anticancer gene therapy

1 reference

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12 September 2017

Cancer-specific viruses and the development of ONYX-015

1 reference

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12 September 2017

Adenoviral gene therapy for cancer: from vectors to targeted and replication competent agents (review).

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12 September 2017

Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer

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12 September 2017

Reprieval from execution: the molecular basis of caspase inhibition

1 reference

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12 September 2017

Prevention of apoptosis by a baculovirus gene during infection of insect cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946310

12 September 2017

Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946310

27 September 2017

Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

1 reference

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27 September 2017

Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946310

27 September 2017

Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma.

1 reference

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27 September 2017

Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosis-like programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946310

27 September 2017

Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy

1 reference

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27 September 2017

Study on mesenchymal stem cells mediated enzyme-prodrug gene CYP1A2 targeting anti-tumor effect

1 reference

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30 May 2018

Treatment of inoperable pancreatic carcinoma using a cell-based local chemotherapy: results of a phase I/II clinical trial.

1 reference

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30 May 2018

Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-487

21 January 2018

Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene

1 reference

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21 January 2018

Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-487

21 January 2018

Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy

1 reference

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21 January 2018

PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo.

1 reference

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21 January 2018

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-487

21 January 2018

A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38.

1 reference

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29 November 2018

Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946310

29 November 2018

Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.

1 reference

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29 November 2018

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

1 reference

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29 November 2018

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

1 reference

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29 November 2018

Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation

1 reference

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29 November 2018

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10.1186/1471-2407-10-487

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