(Q21494550)

English

Interferon gamma

mammalian protein found in Mus musculus

Ifng
gamma interferon
IFN-gamma
interferon 2f
interferon gamma

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

interferon gamma

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01580

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01580

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

cytokine activity

determination method

5 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

protein binding

determination method

1 reference

9 May 2019

Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

interferon-gamma receptor binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

cytokine activity

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

external side of plasma membrane

determination method

9 references

9 May 2019

ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

extracellular space

determination method

21 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Accessory protein-like is essential for IL-18-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

GATA-3 regulates the development and function of invariant NKT cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

24 April 2018

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

extracellular space

determination method

22 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

GATA-3 regulates the development and function of invariant NKT cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

biological process

positive regulation of MHC class II biosynthetic process

determination method

5 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

8 April 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

8 April 2019

Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

8 April 2019

The expression of I-A correlates with the uptake of interferon-gamma by macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

8 April 2019

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

cellular response to interleukin-18

determination method

1 reference

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

adaptive immune response

determination method

1 reference

24 April 2018

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

endoplasmic reticulum unfolded protein response

determination method

1 reference

9 May 2019

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

humoral immune response

determination method

1 reference

24 April 2018

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

determination method

antigen processing and presentation

determination method

1 reference

9 May 2019

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

A novel transactivating factor that regulates interferon-gamma-dependent gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

defense response to bacterium

determination method

1 reference

9 May 2019

Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of T cell proliferation

determination method

1 reference

9 May 2019

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

regulation of immune response

determination method

1 reference

9 May 2019

T-bet regulates T-independent IgG2a class switching

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

neutrophil apoptotic process

determination method

1 reference

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of tumor necrosis factor production

determination method

2 references

9 May 2019

Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

immune response

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

CD8-positive, alpha-beta T cell differentiation involved in immune response

determination method

1 reference

9 May 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of isotype switching to IgG isotypes

determination method

1 reference

9 May 2019

T-bet regulates T-independent IgG2a class switching

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

defense response to protozoan

determination method

regulation of growth

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

cellular response to lipopolysaccharide

determination method

1 reference

9 May 2019

Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

T cell receptor signaling pathway

determination method

1 reference

9 May 2019

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

negative regulation of myelination

determination method

1 reference

9 May 2019

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

inflammatory cell apoptotic process

determination method

1 reference

9 May 2019

Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

defense response to virus

determination method

4 references

9 May 2019

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

regulation of defense response to virus by host

determination method

1 reference

9 May 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

response to virus

determination method

1 reference

9 May 2019

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of epithelial cell migration

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

regulation of protein ADP-ribosylation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of protein-containing complex assembly

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

negative regulation of interleukin-17 production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of interleukin-23 production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of smooth muscle cell apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of osteoclast differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

negative regulation of smooth muscle cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

regulation of insulin secretion

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of membrane protein ectodomain proteolysis

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of killing of cells of other organism

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of fructose 1,6-bisphosphate metabolic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of vitamin D biosynthetic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of calcidiol 1-monooxygenase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of protein serine/threonine kinase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

extrinsic apoptotic signaling pathway

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of core promoter binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

negative regulation of osteoclast differentiation

determination method

1 reference

9 May 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of protein import into nucleus

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

microglial cell activation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of NMDA glutamate receptor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

microglial cell activation

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

receptor signaling pathway via JAK-STAT

determination method

1 reference

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of gene expression

determination method

positive regulation of MHC class II biosynthetic process

determination method

6 references

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

The expression of I-A correlates with the uptake of interferon-gamma by macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

9 May 2019

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of glycolytic process

determination method

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

astrocyte activation

determination method

1 reference

9 May 2019

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of phagocytosis

determination method

1 reference

9 May 2019

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of nitrogen compound metabolic process

determination method

1 reference

9 May 2019

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

neuroinflammatory response

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

negative regulation of amyloid-beta clearance

determination method

positive regulation of neuron death

determination method

1 reference

9 May 2019

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of cellular respiration

determination method

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

positive regulation of amyloid-beta formation

determination method

positive regulation of iron ion import across plasma membrane

determination method

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Encyclopædia Britannica Online ID

science/gamma-interferon

subject named as

gamma interferon

0 references

Ensembl protein ID

ENSMUSP00000063800

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000063800

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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