(Q21494550)

http://www.ebi.ac.uk/interpro/protein/P01580

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01580

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

5 references

24 April 2018

24 April 2018

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

protein binding

IPI

1 reference

9 May 2019

Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

interferon-gamma receptor binding

IPI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

1 reference

9 May 2019

cytokine activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

6 references

9 May 2019

9 May 2019

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

IBA

cell component

extracellular region

external side of plasma membrane

9 references

9 May 2019

ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

extracellular space

21 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

GATA-3 regulates the development and function of invariant NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

24 April 2018

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

extracellular space

22 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

GATA-3 regulates the development and function of invariant NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of MHC class II biosynthetic process

IBA

biological process

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

8 April 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

8 April 2019

Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

8 April 2019

The expression of I-A correlates with the uptake of interferon-gamma by macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

8 April 2019

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

cellular response to interleukin-18

1 reference

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

adaptive immune response

1 reference

24 April 2018

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

endoplasmic reticulum unfolded protein response

1 reference

9 May 2019

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

humoral immune response

1 reference

24 April 2018

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01580&geneProductId=UniProtKB:P01580

antigen processing and presentation

1 reference

9 May 2019

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

regulation of transcription, DNA-templated

1 reference

9 May 2019

A novel transactivating factor that regulates interferon-gamma-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

neutrophil chemotaxis

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

defense response to bacterium

1 reference

9 May 2019

Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of T cell proliferation

1 reference

9 May 2019

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

regulation of immune response

1 reference

9 May 2019

T-bet regulates T-independent IgG2a class switching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

neutrophil apoptotic process

1 reference

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of tumor necrosis factor production

2 references

9 May 2019

Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

1 reference

9 May 2019

CD8-positive, alpha-beta T cell differentiation involved in immune response

1 reference

9 May 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of isotype switching to IgG isotypes

1 reference

9 May 2019

T-bet regulates T-independent IgG2a class switching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

defense response to protozoan

regulation of growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

1 reference

9 May 2019

cellular response to lipopolysaccharide

1 reference

9 May 2019

Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

T cell receptor signaling pathway

1 reference

9 May 2019

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

negative regulation of myelination

1 reference

9 May 2019

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

inflammatory cell apoptotic process

1 reference

9 May 2019

Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of transcription by RNA polymerase II

defense response to virus

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

9 May 2019

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

regulation of defense response to virus by host

1 reference

9 May 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of protein phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

response to virus

1 reference

9 May 2019

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

negative regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of epithelial cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

regulation of protein ADP-ribosylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of protein-containing complex assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

negative regulation of interleukin-17 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of interleukin-23 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of smooth muscle cell apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of osteoclast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

negative regulation of smooth muscle cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

regulation of insulin secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of membrane protein ectodomain proteolysis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of killing of cells of other organism

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of fructose 1,6-bisphosphate metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of vitamin D biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of calcidiol 1-monooxygenase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of protein serine/threonine kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

extrinsic apoptotic signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of core promoter binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

negative regulation of osteoclast differentiation

1 reference

9 May 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of protein import into nucleus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

microglial cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of NMDA glutamate receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

microglial cell activation

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of gene expression

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of MHC class II biosynthetic process

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

The expression of I-A correlates with the uptake of interferon-gamma by macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of glycolytic process

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

astrocyte activation

1 reference

9 May 2019

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of phagocytosis

1 reference

9 May 2019

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of nitrogen compound metabolic process

1 reference

9 May 2019

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of nitric-oxide synthase biosynthetic process

neuroinflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

negative regulation of amyloid-beta clearance

positive regulation of neuron death

1 reference

9 May 2019

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of cellular respiration

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of amyloid-beta formation

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

9 May 2019

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580

positive regulation of iron ion import across plasma membrane

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01580