(Q21494601)

English

Indian hedgehog

mammalian protein found in Mus musculus

Ihh
indian hedgehog protein
HHG-2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Hedgehog signalling/DD-peptidase zinc-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

Hint domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

hedgehog protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Hint domain C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hint domain N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hedgehog protein, Hint domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hedgehog, N-terminal signalling domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

protein binding

determination method

1 reference

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

patched binding

determination method

3 references

patched binding

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Characterization of two patched receptors for the vertebrate hedgehog protein family

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

calcium ion binding

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

plasma membrane

determination method

extracellular space

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

extracellular matrix

determination method

1 reference

8 April 2019

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

biological process

pattern specification process

determination method

1 reference

8 April 2019

Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

positive regulation of collagen biosynthetic process

determination method

1 reference

8 April 2019

Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

negative regulation of T cell differentiation in thymus

determination method

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

cell differentiation

determination method

1 reference

8 April 2019

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

positive regulation of T cell differentiation in thymus

determination method

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

head morphogenesis

determination method

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

negative regulation of immature T cell proliferation in thymus

determination method

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

embryonic pattern specification

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

determination method

1 reference

8 April 2019

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

epithelial cell morphogenesis

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

multicellular organism growth

determination method

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

positive regulation of smoothened signaling pathway

determination method

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

camera-type eye photoreceptor cell fate commitment

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

vitelline membrane formation

determination method

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

negative regulation of eye pigmentation

determination method

1 reference

8 April 2019

Siva is an apoptosis-selective p53 target gene important for neuronal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

cell fate specification

determination method

1 reference

14 February 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

negative regulation of cell differentiation

determination method

1 reference

8 April 2019

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

negative regulation of alpha-beta T cell differentiation

determination method

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

epithelial cell-cell adhesion

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

neuron development

determination method

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

in utero embryonic development

determination method

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

cell maturation

determination method

1 reference

8 April 2019

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

bone resorption

determination method

1 reference

8 April 2019

Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

retinal pigment epithelium development

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

morphogenesis of a branching structure

determination method

1 reference

8 April 2019

Regulation of pancreas development by hedgehog signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

determination method

2 references

somite development

determination method

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

determination method

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

intein-mediated protein splicing

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

vasculature development

determination method

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

proteoglycan metabolic process

determination method

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

positive regulation of mesenchymal cell proliferation

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

embryonic camera-type eye morphogenesis

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

chondrocyte proliferation

determination method

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

positive regulation of cell population proliferation

determination method

4 references

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

smooth muscle tissue development

determination method

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

branching involved in blood vessel morphogenesis

determination method

1 reference

8 April 2019

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

embryonic digestive tract morphogenesis

determination method

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

regulation of growth

determination method

1 reference

8 April 2019

Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

camera-type eye development

determination method

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

positive regulation of alpha-beta T cell differentiation

determination method

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

embryonic skeletal joint development

determination method

1 reference

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

embryonic digit morphogenesis

determination method

cartilage development

determination method

1 reference

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

osteoblast differentiation

determination method

4 references

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

chondrocyte differentiation involved in endochondral bone morphogenesis

determination method

1 reference

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

skeletal system development

determination method

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

smoothened signaling pathway

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

14 February 2019

Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

14 February 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

response to estradiol

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

maternal process involved in female pregnancy

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

response to mechanical stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

liver regeneration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

smoothened signaling pathway

determination method

5 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

determination method

Intein N-terminal splicing region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

Hedgehog, N-terminal signalling domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

Hint domain N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

Hint domain C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

Hedgehog protein, Hint domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97812

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000128056

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000128056

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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