(Q21495776)

Gremlin-1/2

1 reference

DAN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cystine knot, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

vascular endothelial growth factor receptor 2 binding

1 reference

9 May 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

IPI

receptor ligand activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

transmembrane receptor protein tyrosine kinase activator activity

1 reference

9 May 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

heparan sulfate proteoglycan binding

1 reference

9 May 2019

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

intracellular anatomical structure

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70326&geneProductId=UniProtKB:O70326

signal transduction by p53 class mediator

biological process

1 reference

9 May 2019

Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

proximal/distal pattern formation

IGI

1 reference

9 May 2019

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of receptor internalization

1 reference

9 May 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

1 reference

9 May 2019

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of protein tyrosine kinase activity

1 reference

9 May 2019

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

mesenchymal to epithelial transition involved in metanephros morphogenesis

1 reference

9 May 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of signaling receptor activity

1 reference

9 May 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of NF-kappaB transcription factor activity

IGI

1 reference

9 May 2019

Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

embryonic limb morphogenesis

1 reference

9 May 2019

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

1 reference

9 May 2019

Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

ureteric bud formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of peptidyl-tyrosine autophosphorylation

1 reference

9 May 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

animal organ morphogenesis

1 reference

9 May 2019

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

regulation of focal adhesion assembly

1 reference

9 May 2019

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

negative regulation of branching involved in ureteric bud morphogenesis

1 reference

21 June 2018

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70326&geneProductId=UniProtKB:O70326

positive regulation of cardiac muscle cell differentiation

1 reference

9 May 2019

Gremlin enhances the determined path to cardiomyogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

negative regulation of transcription, DNA-templated

1 reference

9 May 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

endothelial cell migration

1 reference

9 May 2019

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

1 reference

9 May 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

regulation of stress-activated MAPK cascade

1 reference

9 May 2019

Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

activation of transmembrane receptor protein tyrosine kinase activity

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

negative regulation of BMP signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

negative regulation of osteoblast differentiation

positive regulation of NIK/NF-kappaB signaling

1 reference

9 May 2019

Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

positive regulation of angiogenesis

positive regulation of branching involved in ureteric bud morphogenesis

3 references

9 May 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

9 May 2019

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70326

has part(s)

Cystine knot, C-terminal

1 reference

DAN

1 reference