(Q21496454)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

DNA-binding transcription factor activity

5 references

9 May 2019

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

21 June 2018

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

steroid hormone receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

nuclear receptor activity

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

3 references

9 May 2019

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

IPI

1 reference

21 June 2018

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

fatty-acyl-CoA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

transcription factor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

palmitoyl-CoA hydrolase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

long-chain fatty acyl-CoA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

sequence-specific DNA binding

arachidonic acid binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

9 May 2019

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

10 references

9 May 2019

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

GATA6 is essential for embryonic development of the liver but dispensable for early heart formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

transcription regulator complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

biological process

phospholipid homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

SMAD protein signal transduction

1 reference

9 May 2019

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

1 reference

9 May 2019

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

regulation of insulin secretion

1 reference

24 April 2018

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

1 reference

9 May 2019

In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

regulation of transcription by RNA polymerase II

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

signal transduction involved in regulation of gene expression

1 reference

9 May 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

1 reference

9 May 2019

Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

positive regulation of transcription, DNA-templated

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

intracellular receptor signaling pathway

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

regulation of gastrulation

1 reference

9 May 2019

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

triglyceride homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

positive regulation of transcription by RNA polymerase II

10 references

9 May 2019

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

steroid hormone mediated signaling pathway

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

endocrine pancreas development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

transcription by RNA polymerase II

TAS

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

cholesterol homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

regulation of transcription, DNA-templated

3 references

acyl-CoA metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

establishment of tissue polarity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

negative regulation of cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

regulation of microvillus assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

negative regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

negative regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

cell-cell junction organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

positive regulation of gluconeogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

positive regulation of fatty acid biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

negative regulation of mitotic cell cycle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

negative regulation of activation of Janus kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

type B pancreatic cell development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

hepatocyte differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

regulation of circadian rhythm

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698

negative regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698