(Q21496783)

Kelch-type beta propeller

1 reference

Galactose oxidase/kelch, beta-propeller

1 reference

V-D-J recombination activating protein 2

1 reference

Recombination activating protein 2, PHD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

1 reference

14 February 2019

ubiquitin protein ligase activity

1 reference

14 February 2019

The RAG1 N-terminal domain is an E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

zinc ion binding

3 references

14 February 2019

A PHD finger motif in the C terminus of RAG2 modulates recombination activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

chromatin binding

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

1 reference

14 February 2019

phosphatidylinositol-3,5-bisphosphate binding

1 reference

14 February 2019

A PHD finger motif in the C terminus of RAG2 modulates recombination activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

phosphatidylinositol-3,4-bisphosphate binding

1 reference

14 February 2019

A PHD finger motif in the C terminus of RAG2 modulates recombination activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

methylated histone binding

protein binding

4 references

14 February 2019

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

Crystal structure of the V(D)J recombinase RAG1-RAG2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

phosphatidylinositol binding

1 reference

14 February 2019

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

phosphatidylinositol-4,5-bisphosphate binding

1 reference

14 February 2019

A PHD finger motif in the C terminus of RAG2 modulates recombination activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

phosphatidylinositol-3,4,5-trisphosphate binding

1 reference

14 February 2019

A PHD finger motif in the C terminus of RAG2 modulates recombination activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

sequence-specific DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

14 February 2019

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

IC

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

1 reference

14 February 2019

TAS

DNA recombinase complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

biological process

DNA recombination

A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

B cell homeostatic proliferation

1 reference

14 February 2019

Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

positive regulation of organ growth

B cell lineage commitment

1 reference

14 February 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

V(D)J recombination

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21784&geneProductId=UniProtKB:P21784

21 June 2018

RAG-1-deficient mice have no mature B and T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21784&geneProductId=UniProtKB:P21784

21 June 2018

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21784&geneProductId=UniProtKB:P21784

pre-B cell allelic exclusion

1 reference

14 February 2019

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

B cell differentiation

4 references

14 February 2019

RAG-1-deficient mice have no mature B and T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

Spi-B can functionally replace PU.1 in myeloid but not lymphoid development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

T cell lineage commitment

1 reference

14 February 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

protein ubiquitination

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

defense response to bacterium

1 reference

14 February 2019

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

chromatin organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

1 reference

14 February 2019

V(D)J recombination

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

RAG-1-deficient mice have no mature B and T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21784

Recombination activating protein 2, PHD domain

has part(s)

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016