(Q21498104)

DHS-like NAD/FAD-binding domain superfamily

1 reference

stated in

Sirtuin, catalytic core small domain superfamily

1 reference

stated in

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transcription corepressor activity

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

protein domain specific binding

1 reference

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

core promoter sequence-specific DNA binding

IPI

1 reference

24 April 2018

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

GAPDH mediates nitrosylation of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

protein deacetylase activity

6 references

9 May 2019

Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Metastasis-associated protein 1 is an integral component of the circadian molecular machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

25 references

9 May 2019

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

Negative control of p53 by Sir2alpha promotes cell survival under stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

3 references

bHLH transcription factor binding

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

NAD-dependent histone deacetylase activity (H3-K9 specific)

1 reference

9 May 2019

GAPDH mediates nitrosylation of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

NAD-dependent protein deacetylase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

DNA-binding transcription activator activity, RNA polymerase II-specific

EXP

NAD-dependent histone deacetylase activity

3 references

21 June 2018

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

protein kinase B binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

10 September 2018

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

1 January 2018

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Negative control of p53 by Sir2alpha promotes cell survival under stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

transcription corepressor activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

protein C-terminus binding

3 references

NAD-dependent histone deacetylase activity

4 references

9 May 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

bHLH transcription factor binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

mitogen-activated protein kinase binding

3 references

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

nuclear inner membrane

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

nuclear inner membrane

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

cellular triglyceride homeostasis

1 reference

9 May 2019

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

DNA synthesis involved in DNA repair

1 reference

9 May 2019

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of adipose tissue development

1 reference

9 May 2019

Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of protein phosphorylation

1 reference

9 May 2019

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

9 May 2019

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

single strand break repair

muscle organ development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

regulation of peroxisome proliferator activated receptor signaling pathway

1 reference

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

regulation of bile acid biosynthetic process

1 reference

9 May 2019

Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of TOR signaling

regulation of glucose metabolic process

1 reference

9 May 2019

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of cellular senescence

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

9 May 2019

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

cellular response to ionizing radiation

IEP

1 reference

9 May 2019

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

cholesterol homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

cellular response to hypoxia

triglyceride mobilization

1 reference

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of prostaglandin biosynthetic process

1 reference

9 May 2019

SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of fat cell differentiation

1 reference

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of peptidyl-lysine acetylation

regulation of transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

positive regulation of adaptive immune response

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

9 May 2019

SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of DNA-binding transcription factor activity

3 references

transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

negative regulation of cAMP-dependent protein kinase activity

pyrimidine dimer repair by nucleotide-excision repair

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of macroautophagy

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of cholesterol efflux

1 reference

9 May 2019

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of macrophage apoptotic process

protein ubiquitination

1 reference

9 May 2019

SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

regulation of lipid storage

1 reference

9 May 2019

Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

regulation of brown fat cell differentiation

1 reference

9 May 2019

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of phosphorylation

negative regulation of neuron death

1 reference

9 May 2019

Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of protein kinase B signaling

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

ovulation from ovarian follicle

1 reference

9 May 2019

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

9 May 2019

Negative control of p53 by Sir2alpha promotes cell survival under stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

leptin-mediated signaling pathway

1 reference

9 May 2019

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of apoptotic process

negative regulation of transcription by RNA polymerase II

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of I-kappaB kinase/NF-kappaB signaling

circadian regulation of gene expression

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

macrophage differentiation

1 reference

9 May 2019

Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

protein deacetylation

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

macrophage cytokine production

1 reference

9 May 2019

Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

fatty acid homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

regulation of mitotic cell cycle

protein destabilization

positive regulation of cAMP-dependent protein kinase activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

white fat cell differentiation

1 reference

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of insulin receptor signaling pathway

negative regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

14 February 2019

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of NF-kappaB transcription factor activity

response to hydrogen peroxide

negative regulation of cellular senescence

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

regulation of smooth muscle cell apoptotic process

1 reference

9 May 2019

SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

behavioral response to starvation

1 reference

9 May 2019

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

cellular glucose homeostasis

1 reference

9 May 2019

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

cellular response to starvation

1 reference

9 May 2019

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

cellular response to tumor necrosis factor

positive regulation of DNA repair

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of cell population proliferation

regulation of endodeoxyribonuclease activity

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

9 May 2019

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

histone deacetylation

6 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

GAPDH mediates nitrosylation of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of transcription by RNA polymerase II

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

histone H3-K9 deacetylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

histone H3-K9 modification

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

positive regulation of smooth muscle cell differentiation

1 reference

9 May 2019

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of histone H3-K9 trimethylation

1 reference

9 May 2019

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of apoptotic process

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

regulation of apoptotic process

cellular response to leukemia inhibitory factor

1 reference

9 May 2019

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of heart rate

IEP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of cardiac muscle cell apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of neuron projection development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of skeletal muscle cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of tumor necrosis factor production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of neuron apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of gluconeogenesis

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4

negative regulation of growth hormone secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of cell death

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of protein deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of protein localization to nucleus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of reactive oxygen species biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of fibroblast apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of thyroid-stimulating hormone secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

positive regulation of cell growth involved in cardiac muscle cell development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

negative regulation of transcription, DNA-templated

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

cellular response to amyloid-beta

histone H3 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4

Sirtuin family, catalytic core domain

has part(s)

1 reference

stated in