(Q21498516)

http://www.ebi.ac.uk/interpro/protein/Q9QYY0

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

5 references

14 February 2019

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

14 February 2019

ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

14 February 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

14 February 2019

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

14 February 2019

The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

signal transducer activity

IPI

1 reference

24 April 2018

Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QYY0&geneProductId=UniProtKB:Q9QYY0

labyrinthine layer development

IDA

biological process

1 reference

14 February 2019

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

interleukin-6-mediated signaling pathway

1 reference

14 February 2019

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

1 reference

14 February 2019

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

platelet-derived growth factor receptor signaling pathway

1 reference

14 February 2019

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

regulation of cell migration

1 reference

14 February 2019

CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

epidermal growth factor receptor signaling pathway

IGI

1 reference

14 February 2019

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

response to oxidative stress

1 reference

14 February 2019

Gab1 is an integrator of cell death versus cell survival signals in oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

1 reference

14 February 2019

Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

positive regulation of MAPK cascade

IDA

1 reference

14 February 2019

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

epidermis development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

cellular response to vascular endothelial growth factor stimulus

1 reference

14 February 2019

The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

positive regulation of cell migration by vascular endothelial growth factor signaling pathway

IDA

1 reference

14 February 2019

The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

actin cytoskeleton reorganization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

response to hepatocyte growth factor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

vascular endothelial growth factor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

positive regulation of angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

endothelial cell chemotaxis to vascular endothelial growth factor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYY0

pleckstrin homology domain

has part(s)

1 reference

stated in

InterPro Release 71.0