(Q21980213)

English

T-box 5

mammalian protein found in Mus musculus

T-box transcription factor TBX5
T-box protein 5
Tbx5

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70326

Transcription factor, T-box

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70326

T-box superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70326

Transcription factor, T-box, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Differential expression and function of Tbx5 and Tbx20 in cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

sequence-specific DNA binding

determination method

3 references

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

14 February 2019

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

14 February 2019

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

DNA-binding transcription factor activity

determination method

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Differential expression and function of Tbx5 and Tbx20 in cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

protein binding

determination method

5 references

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

3 references

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

determination method

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

protein-containing complex

determination method

3 references

protein-DNA complex

determination method

3 references

biological process

pattern specification process

determination method

1 reference

14 February 2019

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

forelimb morphogenesis

determination method

4 references

14 February 2019

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

animal organ development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

ventricular cardiac muscle tissue development

determination method

1 reference

14 February 2019

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

ventricular septum development

determination method

1 reference

14 February 2019

Reptilian heart development and the molecular basis of cardiac chamber evolution

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

bundle of His development

determination method

1 reference

14 February 2019

A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

lung development

determination method

1 reference

14 February 2019

T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

cardiac left ventricle formation

determination method

1 reference

14 February 2019

Reptilian heart development and the molecular basis of cardiac chamber evolution

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

endocardial cushion development

determination method

1 reference

14 February 2019

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

cell-cell signaling

determination method

3 references

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70326&geneProductId=UniProtKB:P70326

determination method

morphogenesis of an epithelium

determination method

1 reference

14 February 2019

T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

positive regulation of transcription, DNA-templated

determination method

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Differential expression and function of Tbx5 and Tbx20 in cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

atrial septum morphogenesis

determination method

1 reference

14 February 2019

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

heart development

determination method

7 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

negative regulation of cell migration

determination method

3 references

positive regulation of cardiac muscle cell proliferation

determination method

1 reference

14 February 2019

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

atrioventricular valve morphogenesis

determination method

1 reference

14 February 2019

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

embryonic limb morphogenesis

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx5 is required for forelimb bud formation and continued outgrowth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

pericardium development

determination method

3 references

positive regulation of cardioblast differentiation

determination method

3 references

positive regulation of secondary heart field cardioblast proliferation

determination method

1 reference

14 February 2019

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

negative regulation of cardiac muscle cell proliferation

determination method

3 references

atrial septum development

determination method

1 reference

14 February 2019

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

embryonic forelimb morphogenesis

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

negative regulation of cell population proliferation

determination method

3 references

transcription by RNA polymerase II

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70326&geneProductId=UniProtKB:P70326

determination method

positive regulation of transcription by RNA polymerase II

determination method

6 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

transdifferentiation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326

determination method

Transcription factor, T-box, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70326

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000018407

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000018407

ENSMUSP00000143828

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000143828

ENSMUSP00000144418

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000144418

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21980213&oldid=2023195865"