(Q28591296)

31 January 2017

title

UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program (English)

1 reference

31 January 2017

main subject

Serum response factor

1 reference

GATA binding protein 4

1 reference

Histone demethylase UTY

1 reference

NK2 homeobox 5

1 reference

1 reference

T-box 5

1 reference

author name string

Seunghee Lee

series ordinal

1

1 reference

31 January 2017

Jae W. Lee

series ordinal

2

1 reference

31 January 2017

Soo-Kyung Lee

series ordinal

3

1 reference

31 January 2017

language of work or name

English

0 references

publication date

17 January 2012

1 reference

31 January 2017

1 reference

31 January 2017

volume

22

1 reference

31 January 2017

issue

1

1 reference

31 January 2017

page(s)

25–37

1 reference

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

31 January 2017

cites work

1 reference

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SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

17 March 2017

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A histone H3 lysine 27 demethylase regulates animal posterior development

17 March 2017

1 reference

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The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

17 March 2017

1 reference

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

17 March 2017

1 reference

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PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

17 March 2017

1 reference

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Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

17 March 2017

1 reference

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Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases

17 March 2017

1 reference

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

17 March 2017

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Control of developmental regulators by Polycomb in human embryonic stem cells

17 March 2017

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Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets

17 March 2017

1 reference

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Restricted inactivation of serum response factor to the cardiovascular system

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

17 March 2017

1 reference

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Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality

17 March 2017

1 reference

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GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

17 March 2017

1 reference

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Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins

17 March 2017

1 reference

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Hop is an unusual homeobox gene that modulates cardiac development

17 March 2017

1 reference

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A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

17 March 2017

1 reference

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Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Polycomb complexes repress developmental regulators in murine embryonic stem cells

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

7 April 2017

1 reference

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A unique chromatin signature uncovers early developmental enhancers in humans

7 April 2017

1 reference

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Chromatin signatures of pluripotent cell lines

7 April 2017

1 reference

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Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Gene regulatory networks in the evolution and development of the heart

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Chromatin regulation by Brg1 underlies heart muscle development and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Phenotypic annotation of the mouse X chromosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Covalent modifications of histones during development and disease pathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Molecular regulation of cardiac chamber-specific gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Differentiation of pluripotent embryonic stem cells into cardiomyocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Transcriptional regulation of vertebrate cardiac morphogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Regulation of the ANF and BNP promoters by GATA factors: lessons learned for cardiac transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Binding of serum response factor to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

GATA transcription factors and cardiac development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

The UTX gene escapes X inactivation in mice and humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

The MADS-box family of transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Combinatorial interactions regulating cardiac transcription

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4111644

Widespread recombinase expression using FLPeR (flipper) mice

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22192413

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.DEVCEL.2011.11.009

1 reference

1 reference

1 reference

1 reference