(Q36994153)

17 August 2017

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title

Covalent modifications of histones during development and disease pathogenesis (English)

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17 August 2017

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3

Ali Shilatifard

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17 August 2017

Sukesh R Bhaumik

1

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PubMed ID

17984963

17 August 2017

Edwin Smith

series ordinal

2

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17 August 2017

5 November 2007

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Nature Structural & Molecular Biology

17 August 2017

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17 August 2017

14

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17 August 2017

11

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17 August 2017

1008-1016

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https://scigraph.springernature.com/pub.10.1038/nsmb1337

17 August 2017

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Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome

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Crystal structure of the nucleosome core particle at 2.8 A resolution

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How does the histone code work?

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Chromatin dynamics at DNA replication, transcription and repair

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Chromatin challenges during DNA replication and repair

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Chromatin modifications and their function

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The role of chromatin during transcription

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Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

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Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression

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Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development

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Histone H3-K9 methyltransferase ESET is essential for early development

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Functions of histone-modifying enzymes in development

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The key to development: interpreting the histone code?

31 March 2020

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Histone arginine methylation regulates pluripotency in the early mouse embryo

31 March 2020

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Functions of site-specific histone acetylation and deacetylation

31 March 2020

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The human Mi-2/NuRD complex and gene regulation

31 March 2020

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Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

31 March 2020

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Transcriptional regulation by histone ubiquitination and deubiquitination.

31 March 2020

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Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation

31 March 2020

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Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.

31 March 2020

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Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

31 March 2020

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A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation

31 March 2020

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The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved

31 March 2020

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Reversible histone modification and the chromosome cell cycle

31 March 2020

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Mitotic chromosome condensation.

31 March 2020

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Histone H2A phosphorylation in DNA double-strand break repair

31 March 2020

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H2B (Ser10) phosphorylation is induced during apoptosis and meiosis in S. cerevisiae

31 March 2020

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Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation

31 March 2020

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Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis.

31 March 2020

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Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development

31 March 2020

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Histone H3 Lys 4 methylation: caught in a bind?

31 March 2020

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Histone lysine demethylases and their impact on epigenetics.

31 March 2020

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Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

31 March 2020

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Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

31 March 2020

1 reference

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

31 March 2020

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Dot1p modulates silencing in yeast by methylation of the nucleosome core

31 March 2020

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Regulation of histone methylation by demethylimination and demethylation

31 March 2020

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Histone demethylation by hydroxylation: chemistry in action

31 March 2020

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Histone lysine demethylases: emerging roles in development, physiology and disease

31 March 2020

1 reference

The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase.

31 March 2020

1 reference

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

31 March 2020

1 reference

The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.

31 March 2020

1 reference

Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins.

31 March 2020

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A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.

31 March 2020

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Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II.

31 March 2020

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Acetylation in histone H3 globular domain regulates gene expression in yeast.

31 March 2020

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Genomic characterization reveals a simple histone H4 acetylation code.

31 March 2020

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Chromatin remodeling in dosage compensation

31 March 2020

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Histone H4-K16 acetylation controls chromatin structure and protein interactions

31 March 2020

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Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern

31 March 2020

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Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

31 March 2020

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The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions

31 March 2020

1 reference

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

31 March 2020

1 reference

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

31 March 2020

1 reference

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

31 March 2020

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

31 March 2020

1 reference

Role of protein methylation in regulation of transcription

31 March 2020

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Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications

31 March 2020

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Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II

31 March 2020

1 reference

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

31 March 2020

1 reference

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

31 March 2020

1 reference

Heterochromatin and epigenetic control of gene expression

31 March 2020

1 reference

Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects

31 March 2020

1 reference

Histone lysine methylation: a signature for chromatin function

31 March 2020

1 reference

Rb targets histone H3 methylation and HP1 to promoters

31 March 2020

1 reference

Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase

31 March 2020

1 reference

Genome-wide histone modifications: gaining specificity by preventing promiscuity

31 March 2020

1 reference

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

31 March 2020

1 reference

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

31 March 2020

1 reference

Historical review: the field of protein methylation

31 March 2020

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Methylation: lost in hydroxylation?

31 March 2020

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Histone methylation: dynamic or static?

31 March 2020

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Reversing histone methylation

31 March 2020

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An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation

31 March 2020

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Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3

31 March 2020

1 reference

A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila.

31 March 2020

1 reference

Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions

31 March 2020

1 reference

Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1

31 March 2020

1 reference

Opposing LSD1 complexes function in developmental gene activation and repression programmes

31 March 2020

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Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development

31 March 2020

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RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3

31 March 2020

1 reference

The retinoblastoma binding protein RBP2 is an H3K4 demethylase

31 March 2020

1 reference

Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein

31 March 2020

1 reference

Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase

31 March 2020

1 reference

The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

31 March 2020

1 reference

The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection

31 March 2020

1 reference

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

31 March 2020

1 reference

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

31 March 2020

1 reference

A histone H3 lysine 27 demethylase regulates animal posterior development

31 March 2020

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PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

31 March 2020

1 reference

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

31 March 2020

1 reference

High-resolution profiling of histone methylations in the human genome

31 March 2020

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

31 March 2020

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Histone deacetylase activity is required for embryonic stem cell differentiation

31 March 2020

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Histone code modifications on pluripotential nuclei of reprogrammed somatic cells

31 March 2020

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Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin

31 March 2020

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The A, B, Gs of silencing

31 March 2020

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Dynamic assembly of silent chromatin during thymocyte maturation

31 March 2020

1 reference

Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.

31 March 2020

1 reference

The role of histones in chromatin remodelling during mammalian spermiogenesis

31 March 2020

1 reference

A haploid affair: core histone transitions during spermatogenesis

31 March 2020

1 reference

Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression

31 March 2020

1 reference

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

31 March 2020

1 reference

Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia.

31 March 2020

1 reference

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development

31 March 2020

1 reference

Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases

31 March 2020

1 reference

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

31 March 2020

1 reference

The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins

31 March 2020

1 reference

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

31 March 2020

1 reference

SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.

31 March 2020

1 reference

An initial blueprint for myogenic differentiation

31 March 2020

1 reference

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart

31 March 2020

1 reference

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

31 March 2020

1 reference

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

31 March 2020

1 reference

The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

31 March 2020

1 reference

The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo

31 March 2020

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Co-evolution of X-chromosome inactivation and imprinting in mammals

31 March 2020

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Reactivation of the paternal X chromosome in early mouse embryos

31 March 2020

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Epigenetic dynamics of imprinted X inactivation during early mouse development

31 March 2020

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Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos.

31 March 2020

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A chromosomal memory triggered by Xist regulates histone methylation in X inactivation

31 March 2020

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Targeted mutagenesis of Tsix leads to nonrandom X inactivation.

31 March 2020

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Regulation of histone H3 lysine 9 methylation in oocytes and early pre-implantation embryos

31 March 2020

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

31 March 2020

1 reference

Towards the human cancer epigenome: a first draft of histone modifications

31 March 2020

1 reference

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

31 March 2020

1 reference

Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes

31 March 2020

1 reference

NSD1 mutations in Sotos syndrome

31 March 2020

1 reference

A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

31 March 2020

1 reference

Unsafe SETs: histone lysine methyltransferases and cancer

31 March 2020

1 reference

Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB1337

1 reference

17 August 2017

1 reference

PubMed ID

17984963