(Q21983012)

Protein-tyrosine phosphatase-like

1 reference

SH2 domain superfamily

1 reference

Tyrosine specific protein phosphatases domain, protein family

1 reference

SH2 domain, protein family

1 reference

PTP type protein phosphatase domain, protein family

1 reference

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

Protein-tyrosine phosphatase, active site, protein family

1 reference

phosphoprotein phosphatase activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

21 references

8 April 2019

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Molecular cloning, biochemical and structural analysis of elongation factor-1 alpha from Leishmania donovani: comparison with the mammalian homologue.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

transmembrane receptor protein tyrosine phosphatase activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

cell adhesion molecule binding

IEA

1 reference

8 April 2019

Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

protein tyrosine phosphatase activity

IPI

10 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The sialoadhesin CD33 is a myeloid-specific inhibitory receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

phosphotyrosine residue binding

natural killer cell lectin-like receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

4 references

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

8 April 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

alpha-beta T cell receptor complex

1 reference

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

B cell receptor signaling pathway

biological process

1 reference

14 February 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

megakaryocyte development

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

intracellular signal transduction

1 reference

8 April 2019

Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

cytokine-mediated signaling pathway

1 reference

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

regulation of release of sequestered calcium ion into cytosol

TAS

1 reference

8 April 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

abortive mitotic cell cycle

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

protein dephosphorylation

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

negative regulation of T cell receptor signaling pathway

1 reference

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

negative regulation of humoral immune response mediated by circulating immunoglobulin

1 reference

8 April 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

negative regulation of T cell proliferation

1 reference

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

negative regulation of peptidyl-tyrosine phosphorylation

hematopoietic progenitor cell differentiation

1 reference

8 April 2019

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

regulation of ERK1 and ERK2 cascade

negative regulation of B cell receptor signaling pathway

1 reference

14 February 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

positive regulation of cell adhesion mediated by integrin

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

cell population proliferation

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

regulation of B cell differentiation

1 reference

8 April 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

natural killer cell mediated cytotoxicity

1 reference

8 April 2019

Mutations in mice that influence natural killer (NK) cell activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

negative regulation of interleukin-6 production

IEA

1 reference

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

1 reference

Protein-tyrosine phosphatase, catalytic

1 reference

PTP type protein phosphatase domain

1 reference

Tyrosine specific protein phosphatases domain

1 reference

Protein-tyrosine phosphatase, active site

1 reference