(Q21987712)

Metallo-dependent phosphatase-like

1 reference

Mre11, DNA-binding domain superfamily

1 reference

Mre11, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Calcineurin-like phosphoesterase

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

manganese ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

1 reference

8 April 2019

3'-5' exonuclease activity

nuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

1 reference

8 April 2019

exonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

1 reference

8 April 2019

protein binding

IPI

cadherin binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

single-stranded DNA endodeoxyribonuclease activity

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

double-stranded telomeric DNA binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

3'-5' exonuclease activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

5'-3' exonuclease activity

single-stranded telomeric DNA binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

3'-5'-exodeoxyribonuclease activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

cell component

telomere

Mre11 complex

PML body

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

IDA

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

1 reference

8 April 2019

condensed nuclear chromosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

nucleus

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

8 April 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

IDA

8 April 2019

The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

perinuclear region of cytoplasm

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

chromatin

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

Mre11 complex

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

site of double-strand break

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

replication fork

site of double-strand break

mitotic intra-S DNA damage checkpoint signaling

chromosome organization

1 reference

8 April 2019

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

cellular response to DNA damage stimulus

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

homologous chromosome pairing at meiosis

1 reference

8 April 2019

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

1 reference

8 April 2019

cell population proliferation

1 reference

8 April 2019

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

mitotic G2 DNA damage checkpoint signaling

1 reference

16 July 2018

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

1 reference

8 April 2019

nucleic acid phosphodiester bond hydrolysis

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

negative regulation of viral entry into host cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

4 references

8 April 2019

8 April 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

telomere maintenance

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

double-strand break repair via homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

3 references

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

base-excision repair

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

double-strand break repair

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

sister chromatid cohesion

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

mitotic intra-S DNA damage checkpoint signaling

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

telomeric 3' overhang formation

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216

meiotic DNA double-strand break formation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

mitochondrial double-strand break repair via homologous recombination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

DNA strand resection involved in replication fork processing

double-strand break repair via homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

double-strand break repair via nonhomologous end joining

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216

Calcineurin-like phosphoesterase domain, ApaH type

has part(s)

1 reference

Mre11, DNA-binding

1 reference