(Q22241434)

17 December 2017

review article

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title

Metformin: new understandings, new uses (English)

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17 December 2017

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2

Silvio E Inzucchi

Silvio E

Inzucchi

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17 December 2017

Ripudaman S Hundal

1

Ripudaman S

Hundal

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17 December 2017

publication date

1 January 2003

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17 December 2017

published in

Drugs

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17 December 2017

volume

63

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17 December 2017

issue

18

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17 December 2017

page(s)

1879-1894

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17 December 2017

Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver

cites work

1 reference

12 December 2020

Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes.

1 reference

12 December 2020

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

1 reference

12 December 2020

Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial.

1 reference

12 December 2020

Lactic acidosis in patients with diabetes treated with metformin

1 reference

12 December 2020

Metformin Causes a Reduction in Basal and Post-venous Occlusion Plasminogen Activator Inhibitor-1 in Type 2 Diabetic Patients

1 reference

12 December 2020

The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog

1 reference

12 December 2020

Mechanism by which metformin reduces glucose production in type 2 diabetes

1 reference

12 December 2020

Enhancement of the mitochondrial Ca2+ uptake rate by phenethylbiguanide and other organic cations with hypoglycemic activity

1 reference

12 December 2020

Metformin reverses fatty liver disease in obese, leptin-deficient mice

1 reference

12 December 2020

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

1 reference

12 December 2020

Effects of metformin on tyrosine kinase activity, glucose transport, and intracellular calcium in rat vascular smooth muscle

1 reference

12 December 2020

Beneficial effects of metformin in normoglycemic morbidly obese adolescents

1 reference

12 December 2020

Medical hazards of obesity

1 reference

12 December 2020

Metformin: a useful adjunct to insulin therapy?

1 reference

12 December 2020

A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients

1 reference

12 December 2020

Pathophysiology and treatment of the dyslipidemia of insulin resistance

1 reference

12 December 2020

Efficacy and safety of acarbose in metformin-treated patients with type 2 diabetes.

1 reference

12 December 2020

Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM.

1 reference

12 December 2020

Use of insulin-sensitizing agents in patients with polycystic ovary syndrome

1 reference

12 December 2020

Metformin in non-alcoholic steatohepatitis.

1 reference

12 December 2020

Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective

1 reference

12 December 2020

Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes

1 reference

12 December 2020

Effect of AMPK activation on muscle glucose metabolism in conscious rats

1 reference

12 December 2020

Metformin lowers lipoprotein(a) levels

1 reference

12 December 2020

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

1 reference

12 December 2020

The management of non-insulin-dependent diabetes during pregnancy

1 reference

12 December 2020

The mechanism of insulin resistance caused by HIV protease inhibitor therapy.

1 reference

12 December 2020

Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors

1 reference

12 December 2020

Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome

1 reference

12 December 2020

Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin

1 reference

12 December 2020

Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis

1 reference

12 December 2020

United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years

1 reference

12 December 2020

Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. The Pioglitazone 027 Study Group

1 reference

12 December 2020

Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells

1 reference

12 December 2020

Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy

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12 December 2020

Effect of metformin on glucose metabolism in the splanchnic bed

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12 December 2020

Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factors

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12 December 2020

Results of a placebo-controlled study of the metabolic effects of the addition of metformin to sulfonylurea-treated patients. Evidence for a central role of adipose tissue

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12 December 2020

C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction

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12 December 2020

Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes.

1 reference

12 December 2020

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

1 reference

12 December 2020

Combined metformin-sulfonylurea treatment of patients with noninsulin-dependent diabetes in fair to poor glycemic control

1 reference

12 December 2020

Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes

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12 December 2020

Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial.

1 reference

12 December 2020

Metformin treatment reduces ovarian cytochrome P-450c17alpha response to human chorionic gonadotrophin in women with insulin resistance-related polycystic ovary syndrome.

1 reference

12 December 2020

Drugs affecting homocysteine metabolism: impact on cardiovascular risk

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12 December 2020

Menstrual cyclicity after metformin therapy in polycystic ovary syndrome.

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12 December 2020

Improved endothelial function with metformin in type 2 diabetes mellitus

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12 December 2020

Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity

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12 December 2020

Increased mortality in Type II diabetic patients using sulphonylurea and metformin in combination: a population-based observational study

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12 December 2020

Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone

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12 December 2020

Nonalcoholic fatty liver disease

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12 December 2020

Central role of the adipocyte in insulin resistance

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12 December 2020

Improved control of mealtime glucose excursions with coadministration of nateglinide and metformin.

1 reference

12 December 2020

Oral antihyperglycemic therapy for type 2 diabetes: scientific review

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12 December 2020

Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients

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12 December 2020

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

1 reference

12 December 2020

Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects

1 reference

12 December 2020

Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial

1 reference

12 December 2020

Treatment with metformin of non-diabetic men with hypertension, hypertriglyceridaemia and central fat distribution: the BIGPRO 1.2 trial.

1 reference

12 December 2020

Metformin prevents weight gain by reducing dietary intake during insulin therapy in patients with type 2 diabetes mellitus

1 reference

12 December 2020

Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity

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12 December 2020

Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study

1 reference

12 December 2020

The effects of metformin on glycemic control and serum lipids in insulin-treated NIDDM patients with suboptimal metabolic control.

1 reference

12 December 2020

Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups.

1 reference

12 December 2020

Metformin, the rebirth of a biguanide: mechanism of action and place in the prevention and treatment of insulin resistance

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12 December 2020

Oral antidiabetic combination therapy with sulphonylureas and metformin.

1 reference

12 December 2020

Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome

1 reference

12 December 2020

Accumulation of metformin by tissues of the normal and diabetic mouse

1 reference

12 December 2020

Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations. A double-blind controlled study.

1 reference

12 December 2020

Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women

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12 December 2020

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

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12 December 2020

Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30.

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12 December 2020

The effect of metformin on hirsutism in polycystic ovary syndrome

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12 December 2020

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

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12 December 2020

Hyperinsulinemia as an independent risk factor for ischemic heart disease.

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12 December 2020

Role of AMP-activated protein kinase in mechanism of metformin action

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12 December 2020

The Phenformin Ban: Is the Drug an Imminent Hazard?

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12 December 2020

Polycystic ovary syndrome: clinical perspectives and management

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12 December 2020

Inhibitory effect of metformin on intestinal glucose absorption in the perfused rat intestine

1 reference

12 December 2020

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.

1 reference

12 December 2020

1 reference

12 December 2020

Metformin for obese, insulin-treated diabetic patients: improvement in glycaemic control and reduction of metabolic risk factors.

1 reference

12 December 2020

Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome.

1 reference

12 December 2020

Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study

1 reference

12 December 2020

The blooming of the French lilac

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12 December 2020

Double-blind evaluation of efficacy and tolerability of metformin in NIDDM.

1 reference

12 December 2020

The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms

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12 December 2020

Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production

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12 December 2020

1 reference

12 December 2020

Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.

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12 December 2020

Clinical pharmacokinetics of metformin

1 reference

12 December 2020

Can metformin reduce insulin resistance in polycystic ovary syndrome?

1 reference

12 December 2020

Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.

1 reference

12 December 2020

The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes

1 reference

12 December 2020

Metformin for weight loss in pediatric patients taking psychotropic drugs

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12 December 2020

Combining sulfonylureas and other oral agents

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12 December 2020

Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome.

1 reference

12 December 2020

Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations

1 reference

12 December 2020

Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

1 reference

12 December 2020

Short-term effects of metformin on insulin sensitivity and sodium homeostasis in essential hypertensives

1 reference

12 December 2020

Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome.

1 reference

12 December 2020

Insulin-metformin combination therapy in obese patients with type 2 diabetes

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12 December 2020

Effects of metformin on early pregnancy loss in the polycystic ovary syndrome

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12 December 2020

Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome

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12 December 2020

Metformin in management of pregnant insulin-independent diabetics

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12 December 2020

Pathophysiology of hypertension and endothelial dysfunction in patients with diabetes mellitus

1 reference

12 December 2020

A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome

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12 December 2020

Weight change and diabetes incidence: findings from a national cohort of US adults

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12 December 2020

Efficacy of metformin in the treatment of NIDDM. Meta-analysis

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12 December 2020

Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome

1 reference

12 December 2020

Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome.

1 reference

12 December 2020

Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial

1 reference

12 December 2020

Nateglinide improves glycaemic control when added to metformin monotherapy: results of a randomized trial with type 2 diabetes patients

1 reference

12 December 2020

Should patients with polycystic ovary syndrome be treated with metformin? Benefits of insulin sensitizing drugs in polycystic ovary syndrome--beyond ovulation induction

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12 December 2020

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

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12 December 2020

Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.

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12 December 2020

Long-term glycaemic improvement after addition of metformin to insulin in insulin-treated obese type 2 diabetes patients

1 reference

12 December 2020

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study

1 reference

12 December 2020

Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.

1 reference

12 December 2020

Repaglinide in combination therapy with metformin in Type 2 diabetes.

1 reference

12 December 2020

Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients.

1 reference

12 December 2020

Effects of metformin on insulin resistance and central adiposity in patients receiving effective protease inhibitor therapy

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12 December 2020

Improvement of insulin sensitivity by metformin treatment does not lower blood pressure of nonobese insulin-resistant hypertensive patients with normal glucose tolerance

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12 December 2020

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

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12 December 2020

Insulin resistance in essential hypertension

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12 December 2020

Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation.

1 reference

12 December 2020

Pharmacologic therapy for type 2 diabetes mellitus

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12 December 2020

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

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12 December 2020

The antidiabetic drug metformin elevates receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate mass in Xenopus oocytes.

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12 December 2020

Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial

1 reference

12 December 2020

Epidemiology of insulin resistance and its relation to coronary artery disease

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12 December 2020

Increased PAI-1 and tPA antigen levels are reduced with metformin therapy in HIV-infected patients with fat redistribution and insulin resistance

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12 December 2020

Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

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12 December 2020

Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia

1 reference

12 December 2020

Type 2 diabetes mellitus in children: primary care and public health considerations

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12 December 2020

Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women.

1 reference

12 December 2020

Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.

1 reference

12 December 2020

Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy

1 reference

12 December 2020

The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution. BIGPRO Study Group.

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12 December 2020

Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome

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12 December 2020

Insulin resistance, polycystic ovary syndrome and metformin

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12 December 2020

Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome.

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12 December 2020

The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes

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12 December 2020

Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study

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12 December 2020

Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome

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12 December 2020

Metabolic effects of indinavir in healthy HIV-seronegative men

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12 December 2020

ETB receptor activation leads to activation and phosphorylation of NHE3.

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003495-200363180-00001

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.2165/00003495-200363180-00001

1 reference

17 December 2017

Dimensions Publication ID

0 references

1 reference

17 December 2017