(Q22678624)

hierarchical database ID heuristic

30 September 2019

based on heuristic

part of

NPC1:NPC2

1 reference

Transporter Classification Database ID

2.A.6.6.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 January 2018

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 January 2018

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 January 2018

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

3 references

9 May 2019

Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

cholesterol transfer activity

IPI

3 references

8 April 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

8 April 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

8 April 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

4 references

9 May 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

cholesterol transfer activity

IBA

3 references

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Identification of HE1 as the second gene of Niemann-Pick C disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

extracellular exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

endoplasmic reticulum

1 reference

9 May 2019

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

IEA

azurophil granule lumen

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 reference

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

IMP

extracellular exosome

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

intracellular sterol transport

HDA

biological process

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

regulation of isoprenoid metabolic process

1 reference

9 May 2019

In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

phospholipid transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

cholesterol transport

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 January 2018

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 January 2018

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 reference

9 May 2019

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

IEP

cholesterol homeostasis

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

steroid metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

intracellular cholesterol transport

5 references

26 September 2017

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

26 September 2017

Regulation of sterol transport between membranes and NPC2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

26 September 2017

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

cholesterol metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

IEA

neutrophil degranulation

1 reference

9 May 2019

low-density lipoprotein particle clearance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

intracellular cholesterol transport

IEA

6 references

8 April 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

8 April 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

8 April 2019

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

8 April 2019

Regulation of sterol transport between membranes and NPC2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

8 April 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

cholesterol homeostasis

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

IMP

cholesterol transport

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

intracellular cholesterol transport

IBA

7 references

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Regulation of sterol transport between membranes and NPC2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

Transporter Classification Database ID

IBA

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

2.A.6.6.1

2 references

stated in

Transporter Classification database

Transporter Classification database

13 March 2020

stated in