(Q27706522)

NPC intracellular cholesterol transporter 1

GOA release 2020-03-11

1 reference

cholesterol transfer activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Nieng Yan

14

0 references

George F. Gao

12

object named as

George F Gao

0 references

Yi Shi

11

object named as

Yi Shi

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author name string

Xin Gong

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238017%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Hongwu Qian

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238017%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Xinhui Zhou

3

1 reference

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7 June 2020

Jianping Wu

4

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7 June 2020

Tao Wan

5

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7 June 2020

Pingping Cao

6

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7 June 2020

Weiyun Huang

7

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7 June 2020

Xin Zhao

8

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7 June 2020

Xudong Wang

9

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7 June 2020

Peiyi Wang

10

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7 June 2020

Qiang Zhou

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238017%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Yi Shi

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238017%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

George F Gao

12

1 reference

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7 June 2020

Nieng Yan

14

1 reference

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7 June 2020

language of work or name

English

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publication date

2 June 2016

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published in

Cell

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7 June 2020

volume

165

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7 June 2020

page(s)

1467-1478

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7 June 2020

issue

6

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The NPC1 protein: structure implies function.

7 June 2020

cites work

1 reference

12 December 2020

A Bayesian view on cryo-EM structure determination.

1 reference

12 December 2020

The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol

1 reference

12 December 2020

Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation

1 reference

12 December 2020

A new player in the puzzle of filovirus entry

1 reference

12 December 2020

Identification of HE1 as the second gene of Niemann-Pick C disease

1 reference

12 December 2020

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

12 December 2020

Niemann-Pick C1 disease: correlations between NPC1 mutations, levels of NPC1 protein, and phenotypes emphasize the functional significance of the putative sterol-sensing domain and of the cysteine-rich luminal loop

1 reference

12 December 2020

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

1 reference

12 December 2020

Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells

1 reference

12 December 2020

Prevention of overfitting in cryo-EM structure determination

1 reference

12 December 2020

Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter

1 reference

12 December 2020

Niemann-Pick disease type C.

1 reference

12 December 2020

Bacterial multidrug efflux transporters

1 reference

12 December 2020

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

1 reference

12 December 2020

A coat of glycoconjugates on the inner surface of the lysosomal membrane in the rat kidney

1 reference

12 December 2020

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1 reference

12 December 2020

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

1 reference

12 December 2020

Quantifying the local resolution of cryo-EM density maps

1 reference

12 December 2020

Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution

1 reference

12 December 2020

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

1 reference

12 December 2020

Host cell factors in filovirus entry: novel players, new insights

1 reference

12 December 2020

Filovirus entry: a novelty in the viral fusion world

1 reference

12 December 2020

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

1 reference

12 December 2020

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

1 reference

12 December 2020

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

12 December 2020

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.

1 reference

12 December 2020

Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

1 reference

12 December 2020

Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor

1 reference

12 December 2020

Gctf: Real-time CTF determination and correction

1 reference

12 December 2020

The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

1 reference

12 December 2020

Niemann-Pick disease type C

1 reference

12 December 2020

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

1 reference

12 December 2020

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

1 reference

12 December 2020

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

1 reference

12 December 2020

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

1 reference

12 December 2020

Transmembrane molecular pump activity of Niemann-Pick C1 protein

1 reference

12 December 2020

Structural basis of RND-type multidrug exporters

1 reference

12 December 2020

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1 reference

12 December 2020

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

1 reference

12 December 2020

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

1 reference

12 December 2020

1 reference

12 December 2020

Crystal structure of bacterial multidrug efflux transporter AcrB

1 reference

12 December 2020

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.

1 reference

12 December 2020

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport

1 reference

12 December 2020

Complex lipid trafficking in Niemann-Pick disease type C.

1 reference

12 December 2020

Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes

1 reference

12 December 2020

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

1 reference

12 December 2020

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

1 reference

12 December 2020

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

1 reference

12 December 2020

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

1 reference

12 December 2020

RND-type drug eﬄux pumps from Gram-negative bacteria: molecular mechanism and inhibition

1 reference

12 December 2020

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

1 reference

12 December 2020

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

1 reference

12 December 2020

The sterol-sensing domain: multiple families, a unique role?

1 reference

12 December 2020

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

1 reference

12 December 2020

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

1 reference

12 December 2020

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

1 reference

12 December 2020

Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

1 reference

12 December 2020

Semi-automated selection of cryo-EM particles in RELION-1.3.

1 reference

12 December 2020

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

1 reference

12 December 2020

Patched acts catalytically to suppress the activity of Smoothened

1 reference

12 December 2020

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

1 reference

12 December 2020

Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa

1 reference

12 December 2020

Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation

1 reference

12 December 2020

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

1 reference

12 December 2020

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

1 reference

12 December 2020

SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles

1 reference

12 December 2020

RELION: implementation of a Bayesian approach to cryo-EM structure determination

1 reference

12 December 2020

10.1016/J.CELL.2016.05.022

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

2703637

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238017%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

2703637

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Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27238017%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

2 references

Consolidated OpenCitations Corpus – April 2017

2703637