(Q40537146)

English

Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation

scientific article published on 7 July 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

transmembrane protein

0 references

author name string

Ram Doolman

1

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Gil S Leichner

2

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Rachel Avner

3

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Joseph Roitelman

4

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

language of work or name

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publication date

7 July 2004

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Europe PubMed Central

PubMed publication ID

21 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

21 September 2017

279

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

37

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

38184-38193

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Regulation of the mevalonate pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Proteolysis and sterol regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Biogenesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an integral glycoprotein of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The ubiquitin system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

N-terminal ubiquitination: more protein substrates join in.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane dom

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

HRD gene dependence of endoplasmic reticulum-associated degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

The nucleotide sequence of Syrian hamster HMG-CoA reductase cDNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405935200

21 January 2018

Identifiers

10.1074/JBC.M405935200

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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