(Q24292106)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0071142

heteromeric SMAD protein complex

1 reference

Gene Ontology release 2020-05-02

1 reference

GOA release 2020-03-11

identical protein binding

1 reference

GOA release 2020-03-11

author name string

B Y Qin

1

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B M Chacko

2

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S S Lam

3

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M P de Caestecker

4

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J J Correia

5

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K Lin

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

6

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language of work or name

English

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publication date

December 2001

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published in

Molecular Cell

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volume

8

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page(s)

1303-12

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issue

6

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Smads as transcriptional co-modulators

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Determinants of specificity in TGF-beta signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Analysis of weight average sedimentation velocity data

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Sedimentation studies reveal a direct role of phosphorylation in Smad3:Smad4 homo- and hetero-trimerization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Characterization of functional domains within Smad4/DPC4

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Smads: transcriptional activators of TGF-beta responses

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Crystal structure of a transcriptionally active Smad4 fragment

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

TGF-beta signaling from receptors to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Mechanism of activation of the TGF-beta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Structural basis of Smad2 recognition by the Smad anchor for receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Formation of a stable heterodimer between Smad2 and Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900417-8

7 January 2021