(Q24295164)

Gene Ontology release 2020-05-02

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903293

Phosphatase and tensin homolog

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Pier Paolo Pandolfi

19

0 references

Jlenia Guarnerio

12

Jlenia Guarnerio

0 references

Antonella Papa

Antonella Papa

1

0 references

Robin M Hobbs

Robin M Hobbs

6

0 references

Leonardo Salmena

Leonardo Salmena

4

0 references

Paolo Pinton

Paolo Pinton

16

0 references

Wenyi Wei

18

Wenyi Wei

0 references

Lixin Wan

2

Lixin Wan

0 references

Roderick Bronson

17

Roderick T Bronson

0 references

Min Sup Song

5

Min Sup Song

0 references

Massimo Bonora

3

Massimo Bonora

0 references

Andrea Lunardi

7

Andrea Lunardi

0 references

author name string

Kaitlyn Webster

8

0 references

Christopher Ng

9

0 references

Ryan H Newton

10

0 references

Nicholas Knoblauch

11

0 references

Keisuke Ito

13

0 references

Laurence A Turka

14

0 references

Andy H Beck

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

15

0 references

language of work or name

English

0 references

publication date

24 April 2014

0 references

published in

Cell

0 references

volume

157

0 references

issue

3

0 references

page(s)

595-610

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Pten dose dictates cancer progression in the prostate

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Phosphorylation of the PTEN tail regulates protein stability and function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

A secreted PTEN phosphatase that enters cells to alter signaling and survival

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Protein tyrosine phosphatases in the human genome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Pten is essential for embryonic development and tumour suppression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Dimerization of Vaccinia virus VH1 is essential for dephosphorylation of STAT1 at tyrosine 701.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Non-genomic loss of PTEN function in cancer: not in my genes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Subtle variations in Pten dose determine cancer susceptibility

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Allele-specific tumor spectrum in pten knockin mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

The Akt kinases: isoform specificity in metabolism and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Post-translational regulation of PTEN.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

The regulation of cell motility and chemotaxis by phospholipid signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Mutations of the human PTEN gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Functional evaluation of p53 and PTEN gene mutations in gliomas.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098792

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24766807

12 December 2020

inferred from PubMed ID database lookup

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24766807

12 December 2020

inferred from PubMed ID database lookup

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2014.03.027

7 January 2021

TCPA: a resource for cancer functional proteomics data

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2014.03.027

7 January 2021

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2014.03.027

7 January 2021

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2014.03.027

7 January 2021

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2014.03.027

7 January 2021

10.1016/J.CELL.2014.03.027

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

24766807

1 reference