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Beyond the cell cycle: a new role for Cdk6 in differentiation
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instance of
scholarly article
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review article
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title
Beyond the cell cycle: a new role for Cdk6 in differentiation
(English)
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main subject
Cyclin dependent kinase 6
1 reference
stated in
GOA release 2020-03-11
negative regulation of cell differentiation
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stated in
GOA release 2020-03-11
author name string
Martha J Grossel
series ordinal
1
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Philip W Hinds
series ordinal
2
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language of work or name
English
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publication date
15 February 2006
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published in
Journal of Cellular Biochemistry
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volume
97
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page(s)
485-93
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issue
3
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cites work
A family of human cdc2-related protein kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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inferred from DOI database lookup
Differential regulation of the synthesis and activity of the major cyclin-dependent kinases, p34cdc2, p33cdk2, and p34cdk4, during cell cycle entry and progression in normal human T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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inferred from DOI database lookup
TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest
1 reference
stated in
Crossref
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7 January 2021
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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
1 reference
stated in
Crossref
reference URL
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7 January 2021
based on heuristic
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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
1 reference
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Crossref
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7 January 2021
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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
1 reference
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7 January 2021
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Transcriptional regulation by a cyclin-cdk.
1 reference
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7 January 2021
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Id proteins in neural cancer.
1 reference
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7 January 2021
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Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle
1 reference
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Crossref
reference URL
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7 January 2021
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p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.
1 reference
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Crossref
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7 January 2021
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Runx transcription factors and the developmental balance between cell proliferation and differentiation.
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Crossref
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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
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Crossref
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7 January 2021
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Radiation-induced cell cycle arrest compromised by p21 deficiency
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Crossref
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Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome
1 reference
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The motor domain determines the large step of myosin-V.
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Cyclin-dependent kinases regulate the antiproliferative function of Smads.
1 reference
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Crossref
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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
1 reference
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Crossref
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Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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The retinoblastoma gene family in differentiation and development.
1 reference
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Crossref
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Accumulation of high levels of the p53 and p130 growth-suppressing proteins in cell lines stably over-expressing cyclin-dependent kinase 6 (cdk6)
1 reference
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Crossref
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CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells
1 reference
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Crossref
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Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
1 reference
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Crossref
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Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G1.
1 reference
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Crossref
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The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
1 reference
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Crossref
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7 January 2021
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cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells.
1 reference
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Crossref
reference URL
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7 January 2021
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The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts
1 reference
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Crossref
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The Id4 HLH protein and the timing of oligodendrocyte differentiation
1 reference
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Crossref
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Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro
1 reference
stated in
Crossref
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7 January 2021
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Shared role of the pRB-related p130 and p107 proteins in limb development
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
1 reference
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Crossref
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7 January 2021
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Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Cell biology. Cell cycle inhibitors may help brake growth as cells develop.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
D-type cyclin-dependent kinase activity in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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inferred from DOI database lookup
Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
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7 January 2021
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Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
retrieved
7 January 2021
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New perspectives on retinoblastoma family functions in differentiation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FJCB.20712
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/JCB.20712
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PubMed ID
16294322
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ResearchGate publication ID
7474947
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