(Q24296551)

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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7

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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7 (English)

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phosphorylation

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based on heuristic

inferred from title

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based on heuristic

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Gonzalo de Prat-Gay

4

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Clara Smal

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author name string

Lucía B Chemes

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Ignacio E Sánchez

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publication date

February 2010

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277

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4

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973-88

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

RB1 gene mutation up-date, a meta-analysis based on 932 reported mutations available in a searchable database

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Cellular mechanisms of tumour suppression by the retinoblastoma gene.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

RB, the conductor that orchestrates life, death and differentiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Retinoblastoma protein partners

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Crystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein Architecture

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Domains A and B in the Rb pocket interact to form a transcriptional repressor motif

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

The human papillomavirus E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Solution structure of the partially folded high-risk human papilloma virus 45 oncoprotein E7.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

The HPV16 E7 viral oncoprotein self-assembles into defined spherical oligomers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Protein intrinsic disorder and human papillomaviruses: increased amount of disorder in E6 and E7 oncoproteins from high risk HPVs.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

High-risk (HPV16) human papillomavirus E7 oncoprotein is highly stable and extended, with conformational transitions that could explain its multiple cellular binding partners

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Molecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequences

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Casein kinase II motif-dependent phosphorylation of human papillomavirus E7 protein promotes p130 degradation and S-phase induction in differentiated human keratinocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Functional analysis of human papillomavirus type 16 E7 by complementation with adenovirus E1A mutants

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structural biology of the tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

PEST sequences and regulation by proteolysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Solvent dependence of PII conformation in model alanine peptides.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Molecular basis for phosphorylation-dependent, PEST-mediated protein turnover

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Elucidating the folding problem of helical peptides using empirical parameters.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Close encounters of the third kind: disordered domains and the interactions of proteins.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Lack of the canonical pRB-binding domain in the E7 ORF of artiodactyl papillomaviruses is associated with the development of fibropapillomas.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Specificity and evolvability in eukaryotic protein interaction networks

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Epigenetic reprogramming by adenovirus e1a.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Fluorescence displacement method for the determination of receptor-ligand binding constants

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Sequence logos: a new way to display consensus sequences

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Clustal W and Clustal X version 2.0

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

The Pfam protein families database

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

The Universal Protein Resource (UniProt) 2009

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

A novel Rb- and p300-binding protein inhibits transactivation by MyoD

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Determination of the binding affinity of different human papillomavirus E7 proteins for the tumour suppressor pRb by a plate-binding assay

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Distinctive Cognate Sequence Discrimination, Bound DNA Conformation, and Binding Modes in the E2 C-Terminal Domains from Prototype Human and Bovine Papillomaviruses†

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

21 January 2018

Germline mutations in the RB1 gene in patients with hereditary retinoblastoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: the amyloid-cancer connection

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Do viral proteins possess unique biophysical features?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative determination of helical propensities from trifluoroethanol titration curves

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Oligomerization properties of the viral oncoproteins adenovirus E1A and human papillomavirus E7 and their complexes with the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cooperative organization in a macromolecular complex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Epidermodysplasia verruciformis-associated human papillomavirus 8: genomic sequence and comparative analysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Adenovirus E1A makes two distinct contacts with the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07540.X

7 January 2021

based on heuristic

inferred from DOI database lookup

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