(Q24296700)

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Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling

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Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling (English)

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Donald P. Bottaro

11

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Deborah Pajalunga

object named as

Deborah Pajalunga

2

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object named as

Daniel C Rabe

5

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author name string

Fabiola Cecchi

1

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C Andrew Fowler

3

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Aykut Uren

4

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Benedetta Peruzzi

6

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Nicholas J Macdonald

7

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Davida K Blackman

8

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Stephen J Stahl

9

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R Andrew Byrd

10

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language of work or name

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publication date

14 August 2012

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22

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250-62

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2

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Cell signaling by receptor tyrosine kinases

1 reference

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19 March 2017

Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling

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19 March 2017

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

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19 March 2017

The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1

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19 March 2017

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

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19 March 2017

Structural basis for agonism and antagonism of hepatocyte growth factor

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19 March 2017

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

19 March 2017

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

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19 March 2017

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

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19 March 2017

Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding

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19 March 2017

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

19 March 2017

The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

19 March 2017

Molecular mapping and functional characterization of the VEGF164 heparin-binding domain

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19 March 2017

Invasive growth: a MET-driven genetic programme for cancer and stem cells

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19 March 2017

The mode of action of heparan and dermatan sulfates in the regulation of hepatocyte growth factor/scatter factor

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19 March 2017

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

1 reference

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19 March 2017

Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

19 March 2017

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1 reference

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19 March 2017

Heparan sulfate proteoglycans

1 reference

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27 September 2017

Multiple mechanisms for exogenous heparin modulation of vascular endothelial growth factor activity

1 reference

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27 September 2017

Targeting the HGF/Met signalling pathway in cancer.

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27 September 2017

Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

From Tpr-Met to Met, tumorigenesis and tubes.

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27 September 2017

Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration

1 reference

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27 September 2017

Structural basis of hepatocyte growth factor/scatter factor and MET signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

The sweet and sour of cancer: glycans as novel therapeutic targets

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27 September 2017

Structural basis for fibroblast growth factor receptor activation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Vascular endothelial growth factor: basic science and clinical progress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

CD44 is required for two consecutive steps in HGF/c-Met signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Kinase insert domain receptor (KDR) extracellular immunoglobulin-like domains 4-7 contain structural features that block receptor dimerization and vascular endothelial growth factor-induced signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Identification and dynamics of a heparin-binding site in hepatocyte growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Identification of heparin-binding stretches of a naturally occurring deleted variant of hepatocyte growth factor (dHGF).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo

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27 September 2017

Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor

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27 September 2017

Emerging multipotent aspects of hepatocyte growth factor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Sulfated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

27 September 2017

Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms. Heparan sulfate glycosaminoglycan requirement for Met binding and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

30 May 2018

Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains

1 reference

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30 May 2018

Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor

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29 November 2018

Functional and biophysical characterization of recombinant human hepatocyte growth factor isoforms produced in Escherichia coli

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422512

29 November 2018

Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22897854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

1 reference

https://pubmed.ncbi.nlm.nih.gov/22897854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22897854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2012.06.029

7 January 2021

based on heuristic

inferred from DOI database lookup

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2012.06.029

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.CCR.2012.06.029

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

release_6ioo25zm2rg2jci4cojn2fppli

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https://api.fatcat.wiki/v0/release/6ioo25zm2rg2jci4cojn2fppli

24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

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