(Q27663368)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Structural basis for agonism and antagonism of hepatocyte growth factor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

main subject

Hepatocyte growth factor

1 reference

MET proto-oncogene, receptor tyrosine kinase

GOA release 2020-03-11

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

William D Tolbert

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

Jennifer Daugherty-Holtrop

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Ermanno Gherardi

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

George Vande Woude

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

H Eric Xu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

language of work or name

English

0 references

publication date

12 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

issue

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

page(s)

13264-13269

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist

7 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Raster3D: photorealistic molecular graphics

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

20 March 2017

https://api.crossref.org/works/10.1073%2FPNAS.1005183107

Further additions to MolScript version 1.4, including reading and contouring of electron-density maps

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Met, metastasis, motility and more

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Novel therapeutic inhibitors of the c-Met signaling pathway in cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Structural basis of hepatocyte growth factor/scatter factor and MET signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Mast cell and neutrophil peptidases attack an inactivation segment in hepatocyte growth factor to generate NK4-like antagonists

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Proliferation and invasion: plasticity in tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Mechanisms and significance of bifunctional NK4 in cancer treatment.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Functional map and domain structure of MET, the product of the c- met protooncogene and receptor for hepatocyte growth factor/scatter factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Differential regulation of hepatocyte growth factor/scatter factor by cell surface proteoglycans and free glycosaminoglycan chains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Alternative proteolytic processing of hepatocyte growth factor during wound repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Site-specific, enzymatic biotinylation of recombinant proteins in Spodoptera frugiperda cells using biotin acceptor peptides.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

The Sema domain of Met is necessary for receptor dimerization and activation

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1005183107

Functional and biophysical characterization of recombinant human hepatocyte growth factor isoforms produced in Escherichia coli

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1005183107

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1005183107

Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922134

HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20624990

12 December 2020

inferred from PubMed ID database lookup

Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20624990

12 December 2020

inferred from PubMed ID database lookup

Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20624990

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1005183107

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

ADS bibcode

2010PNAS..10713264T

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20624990%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

20624990

2 references