(Q28235183)

1

object named as

Carmen Birchmeier

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author name string

Walter Birchmeier

2

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Ermanno Gherardi

3

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George F Vande Woude

Nature Reviews Molecular Cell Biology

4

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language of work or name

English

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publication date

December 2003

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published in

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volume

4

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issue

12

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page(s)

915-25

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cites work

Molecular cloning of a new transforming gene from a chemically transformed human cell line.

1 reference

Mechanism of met oncogene activation

31 March 2020

1 reference

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

31 March 2020

1 reference

Molecular cloning and expression of human hepatocyte growth factor

31 March 2020

1 reference

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

31 March 2020

1 reference

Evidence for the identity of human scatter factor and human hepatocyte growth factor

31 March 2020

1 reference

Hepatocytes and scatter factor

31 March 2020

1 reference

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

31 March 2020

1 reference

Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)

31 March 2020

1 reference

Functional map and domain structure of MET, the product of the c- met protooncogene and receptor for hepatocyte growth factor/scatter factor

31 March 2020

1 reference

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

31 March 2020

1 reference

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

31 March 2020

1 reference

Essential role of Gab1 for signaling by the c-Met receptor in vivo

31 March 2020

1 reference

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

31 March 2020

1 reference

Scatter factor/hepatocyte growth factor is essential for liver development

31 March 2020

1 reference

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

31 March 2020

1 reference

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

31 March 2020

1 reference

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

31 March 2020

1 reference

Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.

31 March 2020

1 reference

Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo

31 March 2020

1 reference

Structure of a heparin-linked biologically active dimer of fibroblast growth factor

31 March 2020

1 reference

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution

31 March 2020

1 reference

Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding

31 March 2020

1 reference

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

31 March 2020

1 reference

Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor

31 March 2020

1 reference

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

31 March 2020

1 reference

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

31 March 2020

1 reference

The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction

31 March 2020

1 reference

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

31 March 2020

1 reference

Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis.

31 March 2020

1 reference

Motogenic and morphogenic activity of epithelial receptor tyrosine kinases

31 March 2020

1 reference

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

31 March 2020

1 reference

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

31 March 2020

1 reference

The "Gab" in signal transduction.

31 March 2020

1 reference

How to make tubes: signaling by the Met receptor tyrosine kinase

31 March 2020

1 reference

Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

31 March 2020

1 reference

Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway

31 March 2020

1 reference

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

31 March 2020

1 reference

Down-regulation of MET, the receptor for hepatocyte growth factor.

31 March 2020

1 reference

Epithelial-mesenchymal transitions in tumour progression

31 March 2020

1 reference

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells

31 March 2020

1 reference

Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

31 March 2020

1 reference

Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

31 March 2020

1 reference

Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

31 March 2020

1 reference

Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway

31 March 2020

1 reference

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

31 March 2020

1 reference

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

31 March 2020

1 reference

A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

31 March 2020

1 reference

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair

31 March 2020

1 reference

Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

31 March 2020

1 reference

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

31 March 2020

1 reference

Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

31 March 2020

1 reference

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

31 March 2020

1 reference

Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis

31 March 2020

1 reference

Regulation of epithelial cell migration and tumor formation by beta-catenin signaling

31 March 2020

1 reference

CD44 is required for two consecutive steps in HGF/c-Met signaling.

31 March 2020

1 reference

The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

1 reference

A mechanism of cell survival: sequestration of Fas by the HGF receptor Met.

31 March 2020

1 reference

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

31 March 2020

1 reference

Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

31 March 2020

1 reference

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival

31 March 2020

1 reference

Evolutionary origins of vertebrate appendicular muscle

31 March 2020

1 reference

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

31 March 2020

1 reference

Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development

31 March 2020

1 reference

Hepatocyte growth factor, a versatile signal for developing neurons

31 March 2020

1 reference

31 March 2020

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Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF.

31 March 2020

1 reference

Early treatment with hepatocyte growth factor improves cardiac function in experimental heart failure induced by myocardial infarction

31 March 2020

1 reference

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation

31 March 2020

1 reference

In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis

31 March 2020

1 reference

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

31 March 2020

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Dysregulation of Met receptor tyrosine kinase activity in invasive tumors

31 March 2020

1 reference

Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

31 March 2020

1 reference

Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase

31 March 2020

1 reference

Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells

31 March 2020

1 reference

Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers

31 March 2020

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The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma.

31 March 2020

1 reference

Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo

31 March 2020

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K252a inhibits the oncogenic properties of Met, the HGF receptor

31 March 2020

1 reference

Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions

31 March 2020

1 reference

Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models

31 March 2020

1 reference

NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells

31 March 2020

1 reference

Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene.

31 March 2020

1 reference

Smart drugs: tyrosine kinase inhibitors in cancer therapy

31 March 2020

1 reference

Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents

31 March 2020

1 reference

Perspectives on the development of a molecularly targeted agent

31 March 2020

1 reference

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

1 reference

Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.

31 March 2020

1 reference

A gene-expression signature as a predictor of survival in breast cancer

31 March 2020

1 reference

Radioimmunoscintigraphy of tumors autocrine for human met and hepatocyte growth factor/scatter factor

31 March 2020

1 reference

Activating mutations for the Met tyrosine kinase receptor in human cancer

31 March 2020

1 reference

Crystal structure of the tyrosine kinase domain of the human insulin receptor

31 March 2020

1 reference

Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies

31 March 2020

1 reference

Genes that control the development of migrating muscle precursor cells

31 March 2020

1 reference