(Q24298500)

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3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins

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scholarly article

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3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins (English)

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3-phosphoinositide dependent protein kinase 1

1 reference

GOA release 2020-03-11

negative regulation of transforming growth factor beta receptor signaling pathway

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GOA release 2020-03-11

author name string

Hyun-A Seong

1

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Haiyoung Jung

2

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Kyong-Tai Kim

3

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Hyunjung Ha

4

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language of work or name

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publication date

20 April 2007

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Journal of Biological Chemistry

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282

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16

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12272-89

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Smads as transcriptional co-modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Smads: transcriptional activators of TGF-beta responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Microtubule binding to Smads may regulate TGF beta activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Smad6 inhibits signalling by the TGF-beta superfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Regulation of macrophage migration inhibitory factor and thiol-specific antioxidant protein PAG by direct interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

B-myb proto-oncogene products interact in vivo with each other via the carboxy-terminal conserved region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Macrophage migration inhibitory factor is a determinant of hypoxia-induced apoptosis in colon cancer cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Snail blocks the cell cycle and confers resistance to cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Cyclin-dependent kinases regulate the antiproliferative function of Smads

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Inhibition of Smad antiproliferative function by CDK phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

21 January 2018

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

7 January 2021

based on heuristic

inferred from DOI database lookup

The TGF-beta family and its composite receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

7 January 2021

based on heuristic

inferred from DOI database lookup

Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609279200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M609279200

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release_e4yy67mk2fe5nemrmh5k4tsaqy

1 reference

https://api.fatcat.wiki/v0/release/e4yy67mk2fe5nemrmh5k4tsaqy

24 November 2022

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mapped directly with Wikidata item

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