(Q24306151)

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Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer

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Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer (English)

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bioluminescence

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Christophe Blanquart

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Christophe Blanquart

1

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Nicolas Boute

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Danièle Lacasa

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Tarik Issad

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publication date

September 2005

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Molecular Pharmacology

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68

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3

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885-94

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Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor

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The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

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Structure and function of the type 1 insulin-like growth factor receptor.

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Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth

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Signal transduction by receptors with tyrosine kinase activity

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Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis

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The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy

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The use of resonance energy transfer in high-throughput screening: BRET versus FRET.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Insulin-like growth factors and neoplasia.

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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

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Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors

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Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells

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Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo.

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Regulation of IGF-I receptor signaling in tumor cells.

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Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

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Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

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A bioluminescence resonance energy transfer (BRET) system: application to interacting circadian clock proteins

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Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

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Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells

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Dynamics of protein-tyrosine phosphatases in rat adipocytes

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Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

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Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

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Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells

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Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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Isoproterenol inhibits insulin-stimulated tyrosine phosphorylation of the insulin receptor without increasing its serine/threonine phosphorylation

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Interaction of the insulin receptor with the receptor-like protein tyrosine phosphatases PTPalpha and PTPepsilon in living cells

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

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The IGF system in thyroid cancer: new concepts.

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The three dimensional structure of the type I insulin-like growth factor receptor

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Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins

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10.1124/MOL.105.013151

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