(Q24310262)

Leucine rich repeat kinase 2

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Leucine rich repeat kinase 1

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identical protein binding

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protein heterodimerization activity

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Wolfdieter Springer

3

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author name string

Christian L Klein

1

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Giorgio Rovelli

2

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Christoph Schall

4

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Philipp J Kahle

6

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Thomas Gasser

Journal of Neurochemistry

5

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language of work or name

English

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publication date

November 2009

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published in

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volume

111

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issue

3

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page(s)

703-15

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cites work

Autosomal dominant parkinsonism associated with variable synuclein and tau pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Roc, a Ras/GTPase domain in complex proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Features of selective kinase inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

LRRK2 in Parkinson's disease: protein domains and functional insights

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Molecular cloning and developmental expression of a rat homologue of death-associated protein kinase in the nervous system

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Kinase activity of mutant LRRK2 mediates neuronal toxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The Parkinson disease gene LRRK2: evolutionary and structural insights

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Distribution of PINK1 and LRRK2 in rat and mouse brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Protein kinase inhibitors: insights into drug design from structure.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Regulation and role of Raf-1/B-Raf heterodimerization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

The death-associated protein kinases: structure, function, and beyond

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Diagnosis and treatment of Parkinson disease: molecules to medicine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021

Update on the functional biology of Lrrk2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06358.X

7 January 2021