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Identification of cholesterol-regulating genes by targeted RNAi screening
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scholarly article
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title
Identification of cholesterol-regulating genes by targeted RNAi screening
(English)
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main subject
Transmembrane protein 97
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stated in
GOA release 2020-03-11
cholesterol homeostasis
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stated in
GOA release 2020-03-11
author
Rainer Pepperkok
object named as
Rainer Pepperkok
series ordinal
10
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Holger Erfle
series ordinal
8
object named as
Holger Erfle
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Martina U Muckenthaler
series ordinal
9
object named as
Martina Muckenthaler
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author name string
Fabian Bartz
series ordinal
1
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Luise Kern
series ordinal
2
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Dorothee Erz
series ordinal
3
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Mingang Zhu
series ordinal
4
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Daniel Gilbert
series ordinal
5
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Till Meinhof
series ordinal
6
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Ute Wirkner
series ordinal
7
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Heiko Runz
series ordinal
11
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language of work or name
English
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publication date
July 2009
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published in
Cell Metabolism
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volume
10
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page(s)
63-75
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issue
1
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cites work
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
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Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Multiple glycolipid elevations (including lactosylceramidosis), partial enzyme deficiencies and ultrastructure of the skin in this generalized sphi
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SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction
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Crossref
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Protein sensors for membrane sterols
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An RNAi screening platform to identify secretion machinery in mammalian cells
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A microscope-based screening platform for large-scale functional protein analysis in intact cells
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reference URL
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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes
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Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles
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Role of cholesterol and lipid organization in disease
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The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane.
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Cohort studies and the genetics of complex disease
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High-throughput RNAi screening by time-lapse imaging of live human cells
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Reverse transfection on cell arrays for high content screening microscopy.
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Cellular cholesterol trafficking and compartmentalization
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Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G.
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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
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Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex
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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
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Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip
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Group C Niemann-Pick disease: faulty regulation of low-density lipoprotein uptake and cholesterol storage in cultured fibroblasts
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Novel interaction partners of the TPR/MET tyrosine kinase
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LRP6 mutation in a family with early coronary disease and metabolic risk factors
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Identification of HE1 as the second gene of Niemann-Pick C disease
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Cholesterol sensing, trafficking, and esterification.
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Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis.
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Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance
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DetecTiff: a novel image analysis routine for high-content screening microscopy
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Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis.
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Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer
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Identifiers
DOI
10.1016/J.CMET.2009.05.009
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4647873
OpenCitations bibliographic resource ID
4647873
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4647873
PubMed ID
19583955
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4647873
ResearchGate publication ID
26653451
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