(Q37064008)

18 August 2017

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title

Cellular cholesterol trafficking and compartmentalization (English)

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18 August 2017

1

Elina Ikonen

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18 August 2017

language of work or name

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1 February 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

published in

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18 August 2017

volume

9

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18 August 2017

issue

2

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18 August 2017

page(s)

125-138

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

18 August 2017

cites work

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31 March 2020

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31 March 2020

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Cargo selection into COPII vesicles is driven by the Sec24p subunit

31 March 2020

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Model systems, lipid rafts, and cell membranes

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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How lipids affect the activities of integral membrane proteins

31 March 2020

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A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers

31 March 2020

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Condensed complexes of cholesterol and phospholipids

31 March 2020

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Lipid rafts: at a crossroad between cell biology and physics.

31 March 2020

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Functional rafts in cell membranes

31 March 2020

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Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts.

31 March 2020

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Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins.

31 March 2020

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A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains

31 March 2020

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Lipid rafts, detergent-resistant membranes, and raft targeting signals

31 March 2020

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Dynamics of putative raft-associated proteins at the cell surface

31 March 2020

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Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization.

31 March 2020

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Nanoscale organization of multiple GPI-anchored proteins in living cell membranes.

31 March 2020

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Lipids and glycosphingolipids in caveolae and surrounding plasma membrane of primary rat adipocytes.

31 March 2020

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Plasma membrane sterol distribution resembles the surface topography of living cells

31 March 2020

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Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

31 March 2020

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Probing red cell membrane cholesterol movement with cyclodextrin

31 March 2020

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Intracellular sterol transport and distribution.

31 March 2020

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Absorption and metabolism of dietary cholesterol

31 March 2020

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Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells

31 March 2020

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Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols

31 March 2020

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Dietary squalene increases cholesterol synthesis measured with serum non-cholesterol sterols after a single oral dose in humans

31 March 2020

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Many facets of mammalian lanosterol 14alpha-demethylase from the evolutionarily conserved cytochrome P450 family CYP51.

31 March 2020

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Liver X Receptor Signaling Pathways in Cardiovascular Disease

31 March 2020

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31 March 2020

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

31 March 2020

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

31 March 2020

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Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

31 March 2020

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Intracellular cholesterol transport

31 March 2020

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Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

31 March 2020

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Molecular machinery for non-vesicular trafficking of ceramide

31 March 2020

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Structure and lipid transport mechanism of a StAR-related domain

31 March 2020

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Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein

31 March 2020

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Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides

31 March 2020

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Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling.

31 March 2020

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Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family

31 March 2020

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Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration.

31 March 2020

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Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.

31 March 2020

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Fate of Endogenously Synthesized Cholesterol in Niemann-Pick Type C1 Cells

31 March 2020

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Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast

31 March 2020

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Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis.

31 March 2020

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Lipid droplets: a unified view of a dynamic organelle

31 March 2020

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A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

31 March 2020

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Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis

31 March 2020

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The multiple faces of caveolae

31 March 2020

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Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: a role for caveolar endocytosis

31 March 2020

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Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes.

31 March 2020

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Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity.

31 March 2020

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Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter

31 March 2020

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Rapid regulation of steroidogenesis by mitochondrial protein import

31 March 2020

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Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.

31 March 2020

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Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol.

31 March 2020

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Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis

31 March 2020

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Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria

31 March 2020

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Is there a mitochondrial signaling complex facilitating cholesterol import?

31 March 2020

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Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids

31 March 2020

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Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

31 March 2020

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Role of LBPA and Alix in multivesicular liposome formation and endosome organization

31 March 2020

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Endosome-to-cytosol transport of viral nucleocapsids

31 March 2020

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The pathophysiology and mechanisms of NP-C disease.

31 March 2020

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Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

31 March 2020

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Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

31 March 2020

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Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease

31 March 2020

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Endocytic trafficking of sphingomyelin depends on its acyl chain length

31 March 2020

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Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution

31 March 2020

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The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells

31 March 2020

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Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport.

31 March 2020

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31 March 2020

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Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.

31 March 2020

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Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

31 March 2020

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The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket

31 March 2020

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MLN64 is involved in actin-mediated dynamics of late endocytic organelles

31 March 2020

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Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin

31 March 2020

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The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components

31 March 2020

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Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells

31 March 2020

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Modulation of cellular cholesterol transport and homeostasis by Rab11.

31 March 2020

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Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling

31 March 2020

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Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells

31 March 2020

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Late endosome motility depends on lipids via the small GTPase Rab7.

31 March 2020

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Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells

31 March 2020

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Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice

31 March 2020

1 reference

ATP-Binding cassette cholesterol transporters and cardiovascular disease

31 March 2020

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Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

31 March 2020

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Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis

31 March 2020

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Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles

31 March 2020

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Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells

31 March 2020

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Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway

31 March 2020

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ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions.

31 March 2020

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Caveolin-1 and regulation of cellular cholesterol homeostasis

31 March 2020

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Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease

31 March 2020

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Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux

31 March 2020

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Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

31 March 2020

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Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow

31 March 2020

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Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice.

31 March 2020

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Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow

31 March 2020

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ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I.

31 March 2020

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ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.

31 March 2020

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Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.

31 March 2020

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Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo

31 March 2020

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SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL.

31 March 2020

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Regulation of intestinal cholesterol absorption

31 March 2020

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

31 March 2020

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Drosophila NPC1b promotes an early step in sterol absorption from the midgut epithelium

31 March 2020

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Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?

31 March 2020

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The intracellular transport of chylomicrons requires the small GTPase, Sar1b

31 March 2020

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Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins

31 March 2020

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Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins

31 March 2020

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31 March 2020

Diabetic dyslipidaemia

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ADP-ribosylation factor 1 and its activation of phospholipase D are important for the assembly of very low density lipoproteins

31 March 2020

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Lipid homeostasis and lipoprotein secretion in Niemann-Pick C1-deficient hepatocytes

31 March 2020

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The role of the LDL receptor in apolipoprotein B secretion

31 March 2020

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Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes

31 March 2020

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Differential Regulation of ATP Binding Cassette Protein A1 Expression and ApoA-I Lipidation by Niemann-Pick Type C1 in Murine Hepatocytes and Macrophages

31 March 2020

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SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells

31 March 2020

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Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells

31 March 2020

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Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis

31 March 2020

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Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

31 March 2020

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Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

31 March 2020

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Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia

31 March 2020

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Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

31 March 2020

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ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

31 March 2020

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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

31 March 2020

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Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

31 March 2020

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Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

31 March 2020

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Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron

31 March 2020

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Survival of adult neurons lacking cholesterol synthesis in vivo

31 March 2020

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Sterol molecule: structure, biosynthesis, and function

31 March 2020

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Golgi structure in three dimensions: functional insights from the normal rat kidney cell

31 March 2020

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The plant ER: a dynamic organelle composed of a large number of discrete functional domains

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2336

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Dimensions Publication ID

18 August 2017

1024968149

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